Claudin-3 Products

Description

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and variations of Claudin expression may have an important role in transcellular transport through tight junctions. In rat liver, claudin-3 is uniformly expressed, whereas in the pancreas, claudin-3 is expressed in junctions of the duct epithelia and junctions of acinar cells. Claudin-3 binds the peptide toxin Clostridium perfringens enterotoxin (CPE) at the cell surface via the second extracellular loop of claudin-3. The gene encoding human claudin-3 maps to chromosome 7q11.23.

Bioinformatics

Entrez	12739 Mouse 1365 Human 65130 Rat
Uniprot	AAH16056 Human NM_001306 Human O15551 Human
Product By Gene ID	1365
Alternate Names	C7orf1 claudin 3 claudin-3 Clostridium perfringens enterotoxin receptor 2 CPE-R 2 CPE-R2 CPETR2CPE-receptor 2 hRVP1 HRVP1 Rat ventral prostate.1 protein homolog RVP1 ventral prostate.1 protein homolog ventral prostate.1-like protein

Research Areas for Claudin-3

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Cell Biology
Cytoskeleton Markers
Extracellular Matrix