Caspase-4 Products

Description

Caspase 4 encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Bioinformatics

Entrez	837 Human
Uniprot	AAA86890 Human AAH17839 Human NM_001225 Human NM_033306 Human NP_001216 Human P49662 Human
Product By Gene ID	837
Alternate Names	apoptotic cysteine protease Mih1/TX CASP-4 caspase 4, apoptosis-related cysteine peptidase caspase 4, apoptosis-related cysteine protease caspase-4 EC 3.4.22 EC 3.4.22.57 ICE(rel)II ICE(rel)-II ICEREL-II ICH2 ICH-2 Mih1/TX Protease ICH-2 Protease TX TX

Research Areas for Caspase-4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases

Related Caspase-4 Blog Posts

Check out the latest blog posts on Caspase-4.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver By Victoria Osinski, PhDWhat is the NLRP3 Inflammasome?With its critical role in innate immunity, the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome ...    Read more.

Caspase-4 - a human protease with roles in inflammation and immunity Caspases are a family of cysteine-aspartic acid proteases that cleave caspase proenzymes as well as other protein substrates. Caspases are well known for their role in apoptosis, but they also play a significant role in other cellular processes inc...    Read more.

Read more Caspase-4 related blogs.