Species: Hu, Mu, Rt
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Sh, Xp
Applications: WB
Host: Rabbit Polyclonal
Species: Mu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
9915 |
| Alternate Names |
- ARNT protein 2
- aryl-hydrocarbon receptor nuclear translocator 2
- bHLHe1BHLHE1
- Class E basic helix-loop-helix protein 1
- KIAA0307aryl hydrocarbon receptor nuclear translocator 2
|
