Antibodies

At Novus Biologicals, we have over 9,000 products on our transduction antibody database. Signal transducers are proteins that facilitate movement of signals, i.e. molecules that cause a reaction, from outside to inside the cell, where they cause changes to cellular function and activity in either the cytoplasm or the nucleus. Transduction pathways are usually activated by complex enzyme cascades, and new proteins are constantly being developed. Thus, our antibody catalogue is constantly being updated.

The end of March has proven to be a busy time for the Novus antibody lab. Seven new antibodies were launched, numerous antibody conjugations completed, and continuous quality control testing of new antibody lots.

We at Novus Biologicals have a number of products in our antibody catalog covering the area of circadian rhythms. Disruptions of the "biological clock" mechanism are known to cause a range of disorders.

We at Novus Biologicals are constantly creating new stem cell lines for a variety of bioassays – they are an essential part of our antibody catalog. Although stem cells are derived from many types of tissue, both adult and human, there is much controversy over their use.

Tumor necrosis factor alpha has been shown to be important in the cellular response to chronic heart failure, with signaling taking place through the receptor isotypes TNFR1 and TNFR2. We at Novus Biologicals have a large number of TNF-related antibodies in our database. Many of today's studies are based on information gained by Defer et al. in 2007.

The CD44 family comprises a number of immunologically similar glycoproteins, which are expressed on the membranes of endothelial, mesenchymal, leukocyte and hepatocyte cells. The CD44 family has a number of functions. CD44 antibody assays have shown some that some isoforms play a role in abnormal gene splicing in human cells.

We at Novus Biologicals have a large number of products in our antibody database which are used for metabolic research. A new Adropin antibody is a recent addition, and is used in obesity research. Although not life-threatening in its own right, obesity – as we all know - can lead to a host of more serious illnesses including heart disease, stroke and diabetes.

Embryonic stem cells (ESCs) and their corresponding marker antibodies are often used in cancer research, since cell-renewal is a feature shared by both ESCs and cancer cells. The drawback is that there is no clear evidence of a transcription program common to both cell types. However, in a study (Wong et al. 2008), it was described how comparison of human and murine ESC-like gene modules had isolated a catalog of 335 genes, which could be used as a "core ESC-like gene module" for tumor studies.

The Novus Product Development Team is excited to announce the launch of a new antibody target not currently available by any other antibody suppliers. The two new antibodies, a human TMEM97 antibody (NBP1-30436) and mouse TMEM97 antibody (NBP1-30437) are of particular interest as TMEM97 is implicated in several cancers, including breast, pancreatic, colorectal and ovarian cancers.

Recent antibody studies have suggested that nuclear factor κB-inducing kinase (NIK) is inhibited through proteasome-controlled degradation regulated by TRAF/cIAP proteins. cIAP1 and cIAP2 are fairly recent apoptosis inhibitors and represent some of the newer products in our antibody catalog.