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Monitoring Autophagy in Neurons

Beclin 1 expression in human cerebellum, Purkinje cells IHC

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
Neuroscience
neurodegeneration
Microglia
Alzheimer's
Parkinson's
Huntington's
Bafilomycin
LC3
p62
NBR1
ATG7

Antigen-loss relapse after successful CAR-T therapy; What do we do now?

Acute lymphoblastic leukemia disease bioinformatics

By Jacqueline Carrico, BS, MD

Tags: 
Cancer
immunology
CAR-T
Tumor
CD19
Siglec-2/CD22
CD20
EGFRvIII

Developmental regulator Daam2 promotes glial cell tumors by degrading Von Hippel-Lindau protein

GFAP expression neuron glia mixed culture ICC

By Jamshed Arslan Pharm.D.

Tags: 
Von Hippel Landau
HIF-1 alpha
Daam2
Neurofibromin 1
PTEN
p53
Bromodeoxyuridine/BrdU
DYKDDDDK Epitope Tag
Myc Epitope Tag
HA Tag

MAPK Signaling Links Autophagy and Inflammation

Autophagy signaling pathway

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
Neuroscience
neurodegeneration
Microglia
Alzheimer’s
Parkinson’s
ATG5
ULK1
MAPK
ERK1
p38
c-Jun
AIF-1/Iba1

Autophagy Inhibition in Cancer: Clinical Trials Update

Autophagy signaling pathway

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
Cancer
Tumor
Chloroquine
Hydroxychloroquine
Beclin 1

Adenosine Inhibits T cell Tumor Infiltration: KCa3.1, a New Anticancer Target

CD8 alpha antibody, ICC

By Yoskaly Lazo-Fernandez, PhD

Tags: 
Cancer
T Cells
Immunotherapy
immunology
Hypoxia
Adenosine A2a R
CD39/ENTPD1
5'-Nucleotidase/CD73

Novel Approaches to Improve Efficacy and Safety of CAR-T Therapy

CAR-T Therapy

By Jacqueline Carrico, BS, MD Candidate

Tags: 
Caspase-9
NOTCH
Cancer
immunology
CAR-T
Tumor

Lysosomal Dysfunction is Linked to Exosomal Secretion

CAR-T Poster

By Christina Towers, PhD.

Tags: 
neurodegeneration
Parkinson's
Alzheimer's
Autophagy
autophagosome
Lysosomes
Huntington's
VPS34
Beclin 1
PI 3-Kinase
p62/SQSTM1
LC3
LAM-1
APP

Targeting Success in CAR-T Therapy for Solid Tumors

CAR-T poster

By Jacqueline Carrico, BS, MD Candidate

Tags: 
ErbB2/Her2
EGFR
EGFRvIII
IL-13 R alpha 2
Cancer
Tumor
Mesothelin

Mitochondrial ATPase inhibitory factor 1 (IF1) provides an explanation of cancer growth in anoxia or pseudo-anoxia

ATPase inhibitor factor 1 antibody ICC

By Jamshed Arslan Pharm.D.

Tags: 
ATPase inhibitor factor 1
ATP synthase C mature
Hypoxia
Cancer

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