PI3K-AKT Signaling Pathway

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The AKT signaling pathway plays an important regulatory role in many cellular survival pathways, primarily as an inhibitor of apoptosis. AKT also plays a regulatory role in angiogenesis and metabolism. The AKT pathway is activated by factors that induce PI3K which in turn activates mTOR pathways. These pathways function in the inhibition of apoptosis as well as cell differentiation and cell cycle. A dysfunctional AKT network has been implicated in several pathological conditions including overgrowth syndromes, carcinogenesis, heart disease, diabetes, autoimmune diseases and inflammation, and neurological disorders. Find available products by clicking on key proteins in the PI3K-AKT interactive pathway below.