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FoxP3 Antibody (376209R) [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications Flow, CyTOF-ready
Clone
376209R
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC8970U-100UG
Alexa Fluor 405
IC8970V-100UG
Alexa Fluor 488
IC8970G-100UG
Alexa Fluor 532
FAB8970X
Alexa Fluor 594
IC8970T-100UG
Alexa Fluor 700
IC8970N-100UG
Alexa Fluor 750
IC8970S-100UG
Allophycocyanin
FAB8970A
Allophycocyanin/Cy7
FAB8970APCCY7
CoraFluor 1
FAB8970CL1
DyLight 350
FAB8970D
DyLight 405
FAB8970E
DyLight 488
FAB8970K
DyLight 550
FAB8970L
DyLight 594
FAB8970M
DyLight 650
FAB8970W
DyLight 680
FAB8970Y
DyLight 755
FAB8970Z
FITC
FAB8970F
HRP
FAB8970H
Janelia Fluor 525
FAB8970JF525
Janelia Fluor 549
FAB8970I
Janelia Fluor 585
FAB8970JF585
Janelia Fluor 635
FAB8970JF635
Janelia Fluor 646
FAB8970J
Janelia Fluor 669
FAB8970JF669
PE/Atto594
FAB8970PEATT594
PE/Cy5.5
FAB8970PECY55
PE/Cy7
FAB8970PECY7
PerCP
FAB8970C
Unconjugated
MAB8970-100
mFluor Violet 450 SE
FAB8970MFV450
mFluor Violet 500 SE
FAB8970MFV500
mFluor Violet 610 SE
FAB8970MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB8970-100
Carrier Free
MAB8970-100
Carrier Free
MAB8970-SP
Carrier Free
IC8970N-100UG
Carrier Free
IC8970G-100UG
Carrier Free
IC8970V-100UG
Carrier Free
IC8970U-100UG
Carrier Free
IC8970T-100UG
Carrier Free
IC8970S-100UG
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FoxP3 Antibody (376209R) [Biotin] Summary

Immunogen
E.coli-derived recombinant human FoxP3
Gln105-Lys200
Accession # Q9BZS1
Specificity
Detects human FoxP3 in direct ELISAs.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified from cell culture supernatant
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from cell culture supernatant

Alternate Names for FoxP3 Antibody (376209R) [Biotin]

  • AIID
  • AIIDMGC141961
  • DIETER
  • forkhead box P3
  • Forkhead Box Protein P3
  • FoxP3
  • FOXP3delta7
  • immune dysregulation, polyendocrinopathy, enteropathy, X-linked
  • Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked
  • IPEX
  • JM2
  • MGC141961
  • MGC141963
  • PIDX
  • PIDXMGC141963
  • SCURFIN
  • XPID
  • XPIDpolyendocrinopathy, enteropathy, X-linked

Background

Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for FoxP3 Antibody (FAB8970B). (Showing 1 - 2 of 2 FAQ).

  1. Does FoxP3 antibodies comes in lyophilized form?
    • FoxP3 antibodies, aka JM2 IPEX, and Scurfin antibodies, have the following products in lyophilized form: NBP1-18319, AF3240.
  2. What the theoretical molecular weight for FoxP3 antibodies?
    • The TMW of FoxP3 antibodies is approximately 47 - 52 kDa.

Secondary Antibodies

 

Isotype Controls

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Bio-Techne brands Novus Biologicals® and R&D Systems® were proud to support the 2nd International Antibody Validation Meeting held at Bath University, on the 15-16 September, 2016. Almost 100 participants from around the world, including funde...  Read full blog post.
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Is has been established that the regulatory transcription factor FOXP3 (a member of the forkhead/winged-helix family of transcription factors) is imperative to immune system homeostasis through CD4+CD25+ regulatory T cell function.  Distinctively, ...  Read full blog post.
FOXP3 is a Master Regulator of T Regulatory (Treg) Cells
FOXP3, a member of forkhead/winged-helix family of transcription factors acts as a "master" regulator for the development and suppressive function of regulatory T cells (Tregs). Its constitutive expression is necessary for the suppressive function of ...  Read full blog post.
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