WRN Antibody

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner Syndrome, an autosomal recessive disorder characterized by premature aging.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: KO, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-472	Applications	Species
Emam A, Wu X, Xu S et al. Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling Nature cell biology 2022-07-01 [PMID: 35817959] (WB, Human)	WB	Human
Barroso-GonzAlez J, GarcIa-ExpOsito L, Galaviz P et al. Anti-recombination function of MutS alpha restricts telomere extension by ALT-associated homology-directed repair Cell reports 2021-12-07 [PMID: 34879271]
Niek van Wietmarschen, Sriram Sridharan, William J Nathan, Anthony Tubbs, Edmond M Chan, Elsa Callen, Wei Wu, Frida Belinky, Veenu Tripathi, Nancy Wong, Kyla Foster, Javad Noorbakhsh, Kiran Garimella, Abimael Cruz-Migoni, Joshua A Sommers, Yongqing Huang, Ashir A Borah, Jonathan T Smith, Jeremie Kalfon, Nikolas Kesten, Kasper Fugger, Robert L Walker, Egor Dolzhenko, Michael A Eberle, Bruce E Hayward, Karen Usdin, Catherine H Freudenreich, Robert M Brosh, Stephen C West, Peter J McHugh, Paul S Meltzer, Adam J Bass, André Nussenzweig Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature 2020-12-14 [PMID: 32999459]
Chan EM, Shibue T, McFarland JM et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers Nature 2019-04-01 [PMID: 30971823] (WB, KO, Mouse, Human)	WB, KO	Mouse, Human
Sidorova JM, Kehrli K, Mao F, Monnat R Jr. Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling DNA Repair (Amst) 2012-12-17 [PMID: 23253856] (WB, Human)	WB	Human
Indig FE, Rybanska I, Karmakar P et al. Nucleolin Inhibits G4 Oligonucleotide Unwinding by Werner Helicase PLoS One 2012-01-01 [PMID: 22675465]
Liu F-J, Barchowsky A, Opresko PL. The Werner Syndrome Protein Functions in Repair of Cr(VI)-Induced Replication-Associated DNA Damage. Toxicol Sci;110(2):307-318. 2009-01-01 [PMID: 19487340]
Sidorova JM, Li N, Folch A et al. The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle. 2008-03-15 [PMID: 18250621] (WB, Human)	WB	Human
Li B, Jog SP, Reddy S et al. WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol 2008-03-01 [PMID: 18212065]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Canine and Feline	06/29/2017	View Summary Application Western Blot Sample Tested Pancreas tissue,Skin tissue,Stomach tissue,Testis tissue Species Canine and Feline Lot A2 Comments Comments This antibody will be used for IHC-P in both canine and feline tissue (results not yet available).

Array NB100-472

• WRN Antibodies
• WRN Protein