TCR gamma/delta Antibody (GL-3) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The gamma δ T-cell receptor (TCR) is a heteromer that includes type I transmembrane CD3 gamma and CD3δ glycoprotein subunits of the Ig superfamily. T gamma δ cells develop as a minor population in the thymus and migrate mainly to in skin and intestinal epithelial layers. Mouse and rat CD3 gamma and CD3δ are synthesized as 182 and 173 amino acid (aa) precursors that result in 160 and 152 aa mature proteins with 94 and 84 aa extracellular domains (ECD), respectively. The germline ECD sequences of CD3 gamma and CD3δ share 71% and 76% aa identity between mouse and rat, respectively, while both proteins and species share 57-62% aa identity with human CD3 gamma and CD3δ. Mouse intraepithelial lymphocytes from the small intestine, which contain a major population of gamma δ T cells, were used as the immunogen for the GL-3/5E11 antibody(1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Flow Cytometry, Neutralization.

Showing Publications 1 - 2 of 2.

Publications using MAB7297	Applications	Species
JM Zou, J Qin, YC Li, Y Wang, D Li, Y Shu, C Luo, SS Wang, G Chi, F Guo, GM Zhang, ZH Feng IL-35 induces N2 phenotype of neutrophils to promote tumor growth Oncotarget, 2017-05-16;8(20):33501-33514. 2017-05-16 [PMID: 28432279] (Neutralization, Mouse)	Neutralization	Mouse
Beck B, Kim H, O'Brien R, Jadus M, Gillespie G, Cloud G, Hoa N, Langford C, Lopez R, Harkins L, Lamb L Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma. PLoS ONE, 2015-05-08;10(5):e0122387. 2015-05-08 [PMID: 25955158] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array MAB7297

• TCR gamma/delta Antibodies