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TACI/TNFRSF13B/CVID Antibody [Biotin]

 (5 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, ELISA(Det)
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Unconjugated
AF174
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF174
Carrier Free
AF174
Carrier Free
AF174-SP
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TACI/TNFRSF13B/CVID Antibody [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human TACI/TNFRSF13B
Ser2-Thr166
Accession # Q53F36
Specificity
Detects human TACI/TNFRSF13B in ELISAs and Western blots. In sandwich immunoassays, less than 1% cross-reactivity with recombinant mouse TACI is observed and less than 0.2% cross-reactivity with recombinant human BCMA is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TNFRSF13B
Purity Statement
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL
Application Notes
ELISA Capture: Human TACI/TNFRSF13B Antibody (Catalog # MAB174)
ELISA Detection: Human TACI/TNFRSF13B Biotinylated Antibody (Catalog # BAF174)
Standard: Recombinant Human TACI/TNFRSF13B Fc Chimera (Catalog # 174-TC)
Readout System
Publications
Read Publications using
BAF174 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TACI/TNFRSF13B/CVID Antibody [Biotin]

  • CD267 antigen
  • CD267
  • CVID
  • CVID2
  • FLJ39942
  • MGC133214
  • TACI
  • TACIMGC39952
  • TNFRSF13B
  • TNFRSF14B
  • Transmembrane activator and CAML interactor
  • tumor necrosis factor receptor 13B
  • tumor necrosis factor receptor superfamily member 13B
  • tumor necrosis factor receptor superfamily, member 13B

Background

TACI, transmembrane activator and CAML-interactor, is a member of the TNF receptor superfamily. TACI is a type III membrane protein with an extracellular N‑terminus in the absence of a cleaved signal sequence. The extracellular region of TACI contains two cysteine rich domains. Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA have both been shown to bind APRIL and BAFF, members of the TNF ligand superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Analogous to BCMA, data suggests that TACI may play an important role in B cell development, function and regulation. Human TACI is a 293 amino acid (aa) protein consisting of a 166 aa extracellular domain, a 20 aa transmembrane domain, and a 107 aa intracellular domain. Human and mouse TACI share 54% amino acid identity.

  1. Xia, X.-Z. et al. (2000) J. Exp. Med. 192:137.
  2. von Bulow, G.U. et al. (1997) Science, 278:138.
  3. Gross, J.A. et al. (2000) Nature 404:995.
  4. Marsters, S.A. et al. (2000) Curr. Biol. 10:785.
  5. Yan, M. et al. (2000) Nature Immunol. 1:37.
  6. Wu, Y. et al. (2000) J. Biol. Chem. 275:35478.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TACI/TNFRSF13B/CVID An
BAF174
TACI/TNFRSF13B/CVID Antibody [Biotin]
Species: Hu
Applications: WB, IHC, ELISA(Det)

Publications for TACI/TNFRSF13B/CVID Antibody (BAF174)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ELISA Development, Flow Cytometry.


Filter By Application
ELISA Development
(1)
Flow Cytometry
(4)
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Human
(5)
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Showing Publications 1 - 5 of 5.
Publications using BAF174 Applications Species
Luster , Troy A, Mukherjee , Ipsita, Carrell , Jeffrey, Cho , Yun Hee, Gill , Jeffrey, Kelly , Lizbeth, Garcia , Andy, Ward , Christop, Oh , Luke, Ullrich , Stephen, Migone , Thi-Sau, Humphreys , Robin Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo. PLoS ONE, 2012-10-09;7(10):e47361. 2012-10-09 [PMID: 23056634] (Flow Cytometry, Human) Flow Cytometry Human
Tak PP, Thurlings RM, Rossier C, Nestorov I, Dimic A, Mircetic V, Rischmueller M, Nasonov E, Shmidt E, Emery P, Munafo A Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arthritis Rheum., 2008-01-01;58(1):61-72. 2008-01-01 [PMID: 18163485] (ELISA Development, Human) ELISA Development Human
Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J. Immunol., 2007-03-01;178(5):2872-82. 2007-03-01 [PMID: 17312131] (Flow Cytometry, Human) Flow Cytometry Human
Elsawa SF, Novak AJ, Grote DM, Ziesmer SC, Witzig TE, Kyle RA, Dillon SR, Harder B, Gross JA, Ansell SM B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. Blood, 2005-11-22;107(7):2882-8. 2005-11-22 [PMID: 16304043] (Flow Cytometry, Human) Flow Cytometry Human
Moir S, Malaspina A, Pickeral OK, Donoghue ET, Vasquez J, Miller NJ, Krishnan SR, Planta MA, Turney JF, Justement JS, Kottilil S, Dybul M, Mican JM, Kovacs C, Chun TW, Birse CE, Fauci AS Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J. Exp. Med., 2004-10-04;200(7):587-99. 2004-10-04 [PMID: 15508184] (Flow Cytometry, Human) Flow Cytometry Human

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Bioinformatics

Gene Symbol TNFRSF13B
Uniprot