Home » Serpin A3/alpha 1-Antichymotrypsin » Serpin A3/alpha 1-Antichymotrypsin Antibodies » Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451) [Janelia Fluor® 646]
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Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, CyTOF-ready
Clone
AACT/1451
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-54339AF350
Alexa Fluor 405
NBP2-54339AF405
Alexa Fluor 488
NBP2-54339AF488
Alexa Fluor 532
NBP2-54339AF532
Alexa Fluor 594
NBP2-54339AF594
Alexa Fluor 647
NBP2-54339AF647
Alexa Fluor 700
NBP2-54339AF700
Alexa Fluor 750
NBP2-54339AF750
Biotin
NBP2-54339B
DyLight 350
NBP2-54339UV
DyLight 405
NBP2-54339V
DyLight 488
NBP2-54339G
DyLight 550
NBP2-54339R
DyLight 594
NBP2-54339DL594
DyLight 650
NBP2-54339C
DyLight 680
NBP2-54339FR
DyLight 755
NBP2-54339IR
FITC
NBP2-54339F
HRP
NBP2-54339H
Janelia Fluor 549
NBP2-54339JF549
Unconjugated
NBP2-54339-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-54339-100ug
Azide and BSA Free
NBP2-54339-100ug
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Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451) [Janelia Fluor® 646] Summary

Immunogen
Recombinant human Serpin A3/alpha 1-Antichymotrypsin protein fragment (around aa 49-187) (exact sequence is proprietary) (Uniprot: P01011)
Localization
Cytoplasmic
Marker
Histiocytoma Marker
Specificity
It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SERPINA3
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451) [Janelia Fluor® 646]

  • AACTMGC88254
  • ACTGIG25
  • alpha 1-Antichymotrypsin
  • alpha-1-antichymotrypsin
  • antitrypsin), member 3
  • Cell growth-inhibiting gene 24/25 protein
  • growth-inhibiting protein 24
  • growth-inhibiting protein 25
  • member 3
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
  • serine (or cysteine) proteinase inhibitor, clade A, member 3
  • Serpin A3
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

Alpha 1 Antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variation in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SERPINA3