SECISBP2 Antibody

SECISBP2 is an RNA binding protein that interacts with the Sec insertion sequence (SECIS) element in selenoprotein mRNAs. The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. Mutations in the SECISBP2 gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NB100-53795	Applications	Species
Papp LV, Wang J, Kennedy D et al. Functional characterization of alternatively spliced human SECISBP2 transcript variants. Nucleic Acids Res 2008-12-01 [PMID: 19004874]
Papp LV, Lu J, Striebel F et al. The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. Mol Cell Biol 2006-07-01 [PMID: 16782878]

Array NB100-53795

• SECISBP2 Antibodies
• SECISBP2 Lysate
• SECISBP2 Protein