RNF7 Antibody

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP1-46159	Applications	Species
Huang DT, Ayrault O, Hunt HW et al. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell 2009-02-27 [PMID: 19250909]

Array NBP1-46159

• RNF7 Antibodies
• RNF7 Lysate
• RNF7 Proteins