RNA Polymerase II/POLR2A [p Ser2] Antibody

The RNA polymerase II subunit B1 (RPB1) is the largest subunit of the RNA polymerase II core complex. RNA polymerase II holoenzyme functions to transcribe DNA into messenger RNA in eukaryotes. RPB1 forms the DNA binding domain of the polymerase that forms a cleft that grabs the incoming DNA template to translocate the holoenzyme across the RNA-DNA hybrid. Alternate identifiers of RPB1 include DNA-directed RNA polymerase II subunit RPB1, DNA directed RNA polymerse II subunit A, DNA-directed RNA polymerase II largest subunit, POLR2A, RPO2, POLRA, RPBh1, RPOL2, RpIILS, hsRPB1, hRPB220, and MGC75453.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Yeast.

We have publications tested in 3 applications: Block/Neutralize, PLA, WB.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using NB100-1805	Applications	Species
Zhang B, Li Y, Zhang J et al. ADAR1 links R-loop homeostasis to ATR activation in replication stress response Nucleic acids research 2023-10-13 [PMID: 37831098]
Igarashi T, Mazevet M, Yasuhara T et al. An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress Nature Communications 2023-08-17 [PMID: 37591859]
Sch�tz M, Wangen C, Sommerer M et al. Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency Virus Research 2023-10-02 [PMID: 37591314] (Block/Neutralize)	Block/Neutralize
Brown RE, Su XA, Fair S et al. The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions PLoS biology 2022-12-27 [PMID: 36574440] (PLA, Yeast)	PLA	Yeast
Matos DA, Zhang JM, Ouyang J et al. ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop Mol. Cell 2019-10-28 [PMID: 31708417]
Tong Z, Mejia A, Veeranki O et al. Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma Ther Adv Med Oncol 2019-01-01 [PMID: 31384313] (WB, Human)	WB	Human
Tong Z, Chatterjee D, Deng D et al. Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma. Oncotarget 2017-04-25 [PMID: 28404924] (WB, Human)	WB	Human
Allepuz-Fuster P, Martinez-Fernandez V, Garrido-Godino Ai et al. Rpb4/7 facilitates RnA polymerase II CTD dephosphorylation. Nucleic Acids Res. 2014-11-21 [PMID: 25416796] (WB, Yeast)	WB	Yeast
Hamasaki T, Okamoto M, Baba M. Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction. Antimicrob Agents Chemother 2013-03-01 [PMID: 23274668] (WB, Human)	WB	Human
Wang X, Hsueh YP, Li W et al. Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. Genes Dev 2010-11-01 [PMID: 21078820]
Yoon YJ, Kim JA, Shin KD et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem 2011-01-01 [PMID: 21078672]
Garrido-Lecca A, Blumenthal T. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Mol Cell Biol 2010-08-01 [PMID: 20498277]
Ma Y, Chen L, Wright GM et al. CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner. J Biol Chem 2010-03-01 [PMID: 20106982]
Nergadze SG, Farnung BO, Wischnewski H et al. CpG-island promoters drive transcription of human telomeres. RNA 2009-12-01 [PMID: 19850908]
Yakir E, Hilman D, Kron I et al. Posttranslational regulation of CIRCADIAN CLOCK ASSOCIATED1 in the circadian oscillator of Arabidopsis. Plant Physiol 2009-06-01 [PMID: 19339503]
Leuenroth SJ, Crews CM. Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure. Cancer Res 2008-07-01 [PMID: 18593926]
Nordick K, Hoffman MG, Betz JL et al. Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II. Eukaryot Cell 2008-07-01 [PMID: 18469135]
Show All 17 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-P	Human	10/29/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested MCF7 Species Human Lot A2
Enlarge	5 reviewed by: Verified Customer	WB	Human	08/26/2014	View Summary Application Western Blot Sample Tested 293T cells Species Human

Array NB100-1805

• RNA Polymerase II/POLR2A Antibodies
• RNA Polymerase II/POLR2A Proteins