RBBP6 Antibody - BSA Free

RBBP6 (retinoblastoma binding protein 6; P2PR, PACT, RBQ1) is a multidomain protein with an expected molecular size of about 250kD and it colocalizes with mitotic chromosomes as well as with NEK6 in centrosomes. RBBP6 is highly expressed in normal placenta and testis, and is overexpressed in certain cancers (esophageal and lung cancer). RBBP6 is a multifunctional protein which is found presumably in all eukaryotes and is implicated in versatile cellular activities such as mRNA metabolism, cell cycle regulation, carcinogenesis, and development. It forms part of the pre-mRNA 3-end processing complex in humans and the cleavage/polyadenylation factor complex in yeast. RBBP6 interacts with p53/TP53, RB1, NEK6, MDM2, YBX1 etc., and gets phosphorylated upon DNA damage via ATM/ATR or through NEK6. RBBP6 is an E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, thereby facilitating its proteasomal degradation. RBBP6 also acts as a scaffold protein to enhance the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, thereby acting as a negative regulator of p53/TP53.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IP, KD, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-49535	Applications	Species
Xiao C, Wu G, Zhou Z et al. RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer Cell Death Dis 2019-11-04 [PMID: 31685801] (IF/IHC, Human)	IF/IHC	Human
Monchusi B, Ntwasa M. Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy PLoS ONE 2017-08-10 [PMID: 28797070] (WB, Human)	WB	Human
Kishikawa T, Otsuka M, Yoshikawa T et al. Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 Nat Commun 2016-09-26 [PMID: 27667193] (ICC/IF, Mouse)	ICC/IF	Mouse
Makgoo L Investigation of the role of arsenic trioxide on the expression of RBBP6 splice variants and their specific micrornas (MIRS) during cell cycle progression and apoptosis Thesis (ICC/IF, Human)	ICC/IF	Human
Ye Z, Xu S, Shi Y Et al. GRB2 enforces homology-directed repair initiation by MRE11 Science advances 2021-08-01 [PMID: 34348893] (IP, KD, Human)	IP, KD	Human

Array NBP1-49535

• RBBP6 Antibodies
• RBBP6 Lysate
• RBBP6 Proteins