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PTIP Antibody [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 646

Order Details

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PTIP Antibody [Janelia Fluor® 646] Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human PAX transcription activation domain interacting protein 1 using the numbering given in Jowsey et akl., 2004, J. Biol. Chem. 279(53):55562-55569 (GeneID 22976).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PAXIP1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PTIP Antibody [Janelia Fluor® 646]

  • CAGF28
  • PACIP1
  • PAX interacting (with transcription-activation domain) protein 1
  • PAX transactivation activation domain-interacting protein
  • PAX transcription activation domain interacting protein 1 like
  • PAX-interacting protein 1
  • PAXIP1LCAGF29
  • protein encoded by CAG trinucleotide repeats
  • PTIPFLJ41049
  • TNRC2

Background

PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. Tandem BRCT (BRCA1 carboxyl-terminal) domains in PTIP and in BRCA1 serve as phosphoserine or phosphothreonine specific binding modules that recognize substrates phosphorylated by the kinases ATM and ATR in response to gamma irradiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PAXIP1