PSD-95 Antibody

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-80875	Applications	Species
Rementer, Cameron, C Engineered Myeloid Precursors Differentiate into Osteoclasts and Resorb Heterotopic Ossification in Mice Research Square 2022-11-07 (ICC/IF)	ICC/IF
Li, Jiaxin, J Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration Research Square 2022-11-29 [PMID: 36814282] (ICC/IF)	ICC/IF
Fourie C, Kim E, Waldvogel H et al. Differential Changes in Postsynaptic Density Proteins in Postmortem Huntingtons Disease and Parkinsons Disease Human Brains. J Neurodegener Dis 2014-01-01 [PMID: 26317010] (IF/IHC, WB, Human)	IF/IHC, WB	Human

Array NBP1-80875

• PSD-95 Antibodies
• PSD-95 Lysate
• PSD-95 Proteins