p62/SQSTM1 Antibody (864807R) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SQSTM1 (Sequestrome-1), also called p62, is a widely expressed, stress-inducible, multifunctional 62 kDa intracellular protein. The 440 amino acid (aa) human SQSTM1 contains multiple adaptor domains that allow interaction with proteins in NGF/NFkB and other signaling pathways (notably TRAF6, atypical protein kinase C family and Src family), polyubiquitin, proteasome subunits and many others. It contains numerous regulatory phosphorylation sites and a dimerization site. SQSTM1 shuttles ubiquitinylated proteins to the proteasome and is important in autophagy and apoptosis. Its dysregulation is associated with Paget’s disease of bone, Parkinson’s and Alzheimer’s diseases, and cancers. Within aa 344-440, which includes the ubiquitin-binding domain, human SQSTM1 shares 100% aa sequence identity with mouse and rat SQSTM1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Immunocytochemistry, Immunoprecipitation, Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB8028R	Applications	Species
Ayoubi, R;Alshafie, W;Shlaifer, I;Southern, K;McPherson, PS;Laflamme, C;NeuroSGC/YCharOS/EDDU collaborative group, ; The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence F1000Research 2024-07-10 [PMID: 39006307] (Immunoprecipitation, Western Blot, Immunocytochemistry, Human)	Immunoprecipitation, Western Blot, Immunocytochemistry	Human

Array MAB8028R

• p62/SQSTM1 Antibodies
• p62/SQSTM1 ELISA Kit
• p62/SQSTM1 Lysate
• p62/SQSTM1 Proteins