Neuropilin-1 Antibody (761704)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neuropilin-1 (Nrp‑1, previously neuropilin; also CD304) is a 130‑140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis (1‑4). The full-length 923 amino acid (aa) mouse Nrp‑1 contains a 623 aa extracellular domain (ECD) that shares 98% aa identity with rat and 93% aa identity with human, equine, bovine and canine Nrp-1 (3, 4). The ECD contains two N‑terminal CUB domains (termed a1a2), two domains with homology to coagulation factors V and VIII (b1b2) and a MAM (meprin) domain (c). At least one splice variant that diverges at aa 587 and lacks the TM domain has been sequenced (5). This form is potentially a soluble antagonist, based on results from human Nrp‑1 splice variants (1, 6‑8). The sema domains of Class III secreted semaphorins such as Sema3A bind Nrp‑1 a1a2 (9). Heparin, the heparin-binding forms of VEGF (VEGF₁₆₅, VEGF-B and VEGF-E), PlGF (PlGF2), and the C‑terminus of Sema3 bind the b1b2 region (9, 10). Nrp‑1 and Nrp-2 share 48% aa identity within the ECD and can form homo‑ and hetero‑oligomers via interaction of their MAM domains (1). Neuropilins show partially overlapping expression in neuronal and endothelial cells during development (1, 2). Both neuropilins act as co‑receptors with plexins, mainly plexin A3 and A4, to bind class III semaphorins that mediate axon repulsion (11). However, only Nrp‑1 binds Sema3A, and only Nrp‑2 binds Sema3F (1). Both are co‑receptors with VEGF R2 (also called KDR or Flk‑1) for VEGF₁₆₅ binding (1). Sema3A signaling can be blocked by VEGF₁₆₅, which has higher affinity for Npn-1 (12). Nrp-1 is preferentially expressed in developing or remodeling arteries (1, 2). Nrp‑1 is also expressed on dendritic cells and mediates DC‑induced T cell proliferation (13).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, Blocking, In Vivo, Neutralization.

Showing Publications 1 - 5 of 5.

Publications using MAB59941	Applications	Species
Schmithals, C;Kakoschky, B;Denk, D;von Harten, M;Klug, JH;Hintermann, E;Dropmann, A;Hamza, E;Jacomin, AC;Marquardt, JU;Zeuzem, S;Schirmacher, P;Herrmann, E;Christen, U;Vogl, TJ;Waidmann, O;Dooley, S;Finkelmeier, F;Piiper, A; Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice EBioMedicine 2024-06-17 [PMID: 38889481] (Neutralization, Mouse)	Neutralization	Mouse
M Leclerc, E Voilin, G Gros, S Corgnac, V de Montpré, P Validire, G Bismuth, F Mami-Choua Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1 Nat Commun, 2019-07-26;10(1):3345. 2019-07-26 [PMID: 31350404] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
MB Jones, CA Alvarez, JL Johnson, JY Zhou, N Morris, BA Cobb CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation PLoS ONE, 2019-05-23;14(5):e0216893. 2019-05-23 [PMID: 31120919] (Blocking, Mouse)	Blocking	Mouse
C McDonald-H, JT Muller, M Loschi, G Thangavelu, A Saha, S Kumari, DK Reichenbac, MJ Smith, G Zhang, BH Koehn, J Lin, JS Mitchell, BT Fife, A Panoskalts, CJ Feser, AK Kirchmeier, MJ Osborn, KL Hippen, A Kelekar, JS Serody, LA Turka, DH Munn, H Chi, TA Neubert, ML Dustin, BR Blazar The vimentin intermediate filament network restrains regulatory T-cell suppression of graft-versus-host disease J. Clin. Invest., 2018-08-14;0(0):. 2018-08-14 [PMID: 30106752] (Neutralization, Mouse)	Neutralization	Mouse
Delgoffe , Greg M, Woo , Seng-Ryo, Turnis , Meghan E, Gravano , David M, Guy , Cliff, Overacre , Abigail, Bettini , Matthew, Vogel , Peter, Finkelstein , David, Bonnevier , Jody, Workman , Creg J, Vignali , Dario A Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature, 2013-08-04;501(7466):252-6. 2013-08-04 [PMID: 23913274] (Mouse)		Mouse

Array MAB59941

• Neuropilin-1 Antibodies
• Neuropilin-1 Lysates
• Neuropilin-1 Protein
• Neuropilin-1 ELISAs
• Neuropilin-1 Proteins and Enzymes