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Mineralocorticoid R/NR3C2 Antibody (NR3C2/4900)

Images

 
Formalin-fixed, paraffin-embedded human kidney stained with NR3C2 Mouse Monoclonal Antibody (NR3C2/4900). Inset: PBS instead of primary antibody; secondary only negative control.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
NR3C2/4900
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

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Mineralocorticoid R/NR3C2 Antibody (NR3C2/4900) Summary

Description
Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant fragment (around aa601-673) of human Mineralocorticoid R/NR3C2 protein
Localization
Nucleus
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
NR3C2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT
Application Notes
Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT. Optimal dilution for a specific application should be determined.. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS with 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for Mineralocorticoid R/NR3C2 Antibody (NR3C2/4900)

  • FLJ41052
  • MGC133092
  • Mineralocorticoid R
  • mineralocorticoid receptor 1
  • mineralocorticoid receptor delta
  • MineralocorticoidR
  • MLR
  • MLRmineralocorticoid receptor
  • MRMCRaldosterone receptor
  • NR3C2
  • NR3C2VIT
  • Nuclear receptor subfamily 3 group C member 2
  • nuclear receptor subfamily 3, group C, member 2

Background

Steroid receptors are ligand dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor and that complex's subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain Mineralocorticoid Receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NR3C2