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IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [Unconjugated]

 
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Western blot shows lysates of Daudi human Burkitt's lymphoma cell line, Raji human Burkitt's lymphoma cell line, BaF3 mouse pro-B cell line, and Nb2-11 rat lymphoma cell line. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human/Mouse/Rat Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 Monoclonal Antibody (Catalog # MAB8349) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 at approximately 56 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Western blot shows lysates of Daudi human Burkitt's lymphoma cell line, Raji human Burkitt's lymphoma cell line, BaF3 mouse pro-B cell line, and Nb2-11 rat lymphoma cell line. PVDF membrane was probed with 0.5 µg/mL of ...read more
Simple Western lane view shows lysates of Daudi human Burkitt's lymphoma cell line, loaded at 0.5 mg/mL. A specific band was detected for Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 at approximately 57 kDa (as ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Simple Western
Clone
911425
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB8349-SP
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IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [Unconjugated] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2
Met1-Phe514
Accession # P12268
Specificity
Detects human Inosine 5'-Monophosphate Dehydrogenase 2/IMPDH2 in direct ELISAs. Detects human, mouse and rat IMPDH2 in Western blots.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IMPDH2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Simple Western 5 ug/mL
  • Western Blot 0.5 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [Unconjugated]

  • EC 1.1.1.205
  • IMDH2
  • IMP (inosine 5'-monophosphate) dehydrogenase 2
  • IMP (inosine monophosphate) dehydrogenase 2
  • IMP Dehydrogenase 2
  • IMP Oxireductase 2
  • IMPD 2
  • IMPD2
  • IMPD2IMP oxireductase 2
  • IMPDH 2
  • IMPDH2
  • IMPDH-II
  • inosine 5' phosphate dehydrogenase 2
  • inosine monophosphate dehydrogenase type II
  • inosine-5'-monophosphate dehydrogenase 2

Background

IMP Dehydrogenase 2 (IMPDH2), also known as type II Inosine 5'-Monophosphate Dehydrogenase and IMPD2, is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis. Along with closely related enzyme IMPDH1, IMPDH2 catalyzes the conversion of Inosine 5’-Phosphate (IMP) to Xanthosine 5’-Phosphate (XMP), and is responsible for maintaining the cellular guanine deoxy- and ribonucleotide pools required for DNA and RNA synthesis, respectively. IMPDH2 regulation is associated with cellular proliferation, transformation and differentiation, and its levels are selectively upregulated in neoplastic and replicating cells. Therefore, it has been evaluated as a target for anti-tumor, anti-infective and immunosuppressive drugs.  Human IMPDH2 is a 56 kDa protein that shares 84% amino acid (aa) identity with human IMPDH1, and 98% aa identity with mouse and rat IMPDH2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IMP Dehydrogenase
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MAB8349
IMP Dehydrogenase 2/IMPDH2 Antibody (911425) [Unconjugated]
Species: Hu, Mu, Rt
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Bioinformatics

Gene Symbol IMPDH2
Uniprot