IL-1 beta/IL-1F2 Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. The 17 kDa molecular weight mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 67%-78% with canine, equine, feline, human, porcine, and rhesus macaque IL-1 beta . IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 7 applications: Bioassay, ELISA Capture, ELISA Detection, ELISA Development, ELISA Development (Detection), Luminex Development, Western Blot.

Showing Publications 1 - 10 of 49. Show All 49 Publications. Collapse Publications.

Publications using BAF401	Applications	Species
Wertman, RS;Yost, W;Herrmann, BI;Bourne, CM;Sorobetea, D;Go, CK;Saller, BS;Gro beta , O;Scott, P;Rongvaux, A;Taabazuing, CY;Brodsky, IE; Distinct sequential death complexes regulate pyroptosis and IL-1? release in response to Yersinia blockade of immune signaling Science advances 2024-07-26 [PMID: 39058785] (ELISA Detection, Mouse)	ELISA Detection	Mouse
Hongxu Xian, Kosuke Watari, Elsa Sanchez-Lopez, Joseph Offenberger, Janset Onyuru, Harini Sampath et al. FEN1-generated oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling Immunity 2022-08-01 [PMID: 35835107]
Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann et al. Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo EMBO Molecular Medicine 2022-06-08 [PMID: 35438238]
Alice J. West, Virginie Deswaerte, Alison C. West, Linden J. Gearing, Patrick Tan, Brendan J. Jenkins Inflammasome-Associated Gastric Tumorigenesis Is Independent of the NLRP3 Pattern Recognition Receptor Frontiers in Oncology 2022-03-01 [PMID: 35299732]
Hongxu Xian, Yuan Liu, Alexandra Rundberg Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte et al. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation Immunity 2021-07-01 [PMID: 34115964]
Gayoung Kim, Kyeong-Hun Choi, Hangeun Kim, Dae-Kyun Chung Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates International Journal of Molecular Sciences 2021-05-31 [PMID: 34072918]
GM Childers, CA Perry, B Blachut, N Martin, CD Bortner, S Sieber, JL Li, MB Fessler, GJ Harry Assessing the Association of Mitochondrial Function and Inflammasome Activation in Murine Macrophages Exposed to Select Mitotoxic Tri-Organotin Compounds Environmental health perspectives, 2021-04-30;129(4):47015. 2021-04-30 [PMID: 33929904] (Western Blot, Mouse)	Western Blot	Mouse
K Tsuchiya, S Hosojima, H Hara, H Kushiyama, MR Mahib, T Kinoshita, T Suda Gasdermin D mediates the maturation and release of IL-1&alpha downstream of inflammasomes Cell Reports, 2021-03-23;34(12):108887. 2021-03-23 [PMID: 33761363] (Western Blot, Mouse)	Western Blot	Mouse
S Van Belle, A de Lange, H Tomes, R Lucas, V Naidoo, JV Raimondo Peripheral Taenia infection increases immunoglobulins in the central nervous system International journal for parasitology, 2021-03-20;51(8):685-692. 2021-03-20 [PMID: 33753094] (Mouse)		Mouse
HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&kappaB&alpha pathway Arthritis Research & Therapy, 2020-09-23;22(1):222. 2020-09-23 [PMID: 32972460] (Human)		Human
DC Shippy, C Wilhelm, PA Viharkumar, TJ Raife, TK Ulland &beta-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology Journal of Neuroinflammation, 2020-09-21;17(1):280. 2020-09-21 [PMID: 32958021] (ELISA Capture, Mouse)	ELISA Capture	Mouse
CA Donado, AB Cao, DP Simmons, BA Croker, PJ Brennan, MB Brenner A Two-Cell Model for IL-1&beta Release Mediated by Death-Receptor Signaling Cell Rep, 2020-04-07;31(1):107466. 2020-04-07 [PMID: 32268091] (Western Blot, Mouse)	Western Blot	Mouse
DG Kim, JW Choi, IJ Jo, MJ Kim, HS Lee, SH Hong, HJ Song, GS Bae, SJ Park Berberine ameliorates lipopolysaccharide?induced inflammatory responses in mouse inner medullary collecting duct?3 cells by downregulation of NF?kappaB pathway Mol Med Rep, 2019-11-19;0(0):. 2019-11-19 [PMID: 31746359] (ELISA Development, Mouse)	ELISA Development	Mouse
Z Pang, R Raudonis, C McCormick, Z Cheng Early growth response 1 deficiency protects host against Pseudomonas aeruginosa lung infection Infect. Immun., 2019-12-17;0(0):. 2019-12-17 [PMID: 31611276] (ELISA Detection, Mouse)	ELISA Detection	Mouse
A Polykratis, A Martens, RO Eren, Y Shirasaki, M Yamagishi, Y Yamaguchi, S Uemura, M Miura, B Holzmann, G Kollias, M Armaka, G van Loo, M Pasparakis A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain Nat. Cell Biol., 2019-05-13;0(0):. 2019-05-13 [PMID: 31086261] (Bioassay, Mouse)	Bioassay	Mouse
Elsa Sanchez-Lopez, Zhenyu Zhong, Alexandra Stubelius, Shannon R. Sweeney, Laela M. Booshehri, Laura Antonucci et al. Choline Uptake and Metabolism Modulate Macrophage IL-1 beta and IL-18 Production Cell Metabolism 2019-06-01 [PMID: 30982734]
Takashi Orimo, Izumi Sasaki, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Tomokazu Ohta et al. Cholera toxin B induces interleukin-1 beta production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome International Immunology 2019-09-18 [PMID: 30689886]
R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4 Oncogene, 2018-12-05;0(0):. 2018-12-05 [PMID: 30518876] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Z Zhong, S Liang, E Sanchez-Lo, F He, S Shalapour, XJ Lin, J Wong, S Ding, E Seki, B Schnabl, AL Hevener, HB Greenberg, T Kisseleva, M Karin New mitochondrial DNA synthesis enables NLRP3 inflammasome activation Nature, 2018-07-25;0(0):. 2018-07-25 [PMID: 30046112] (Mouse)		Mouse
JM Ho, NH Ducich, NK Nguyen, MR Opp Acute sleep disruption- and high-fat diet-induced hypothalamic inflammation are not related to glucose tolerance in mice Neurobiol Sleep Circadian Rhythms, 2018-01-01;4(0):1-9. 1/1/2018 [PMID: 29732438]
NR Han, HY Kim, NR Kim, WK Lee, H Jeong, HM Kim, HJ Jeong Leucine and glycine dipeptides of porcine placenta ameliorate physical fatigue through enhancing dopaminergic systems Mol Med Rep, 2017-12-20;0(0):. 12/20/2017 [PMID: 29286166]
Ivan Zanoni, Yunhao Tan, Marco Di Gioia, James R. Springstead, Jonathan C. Kagan By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation Immunity 2017-10-17 [PMID: 29045901]
Z Pang, RD Junkins, AJ MacNeil, C McCormick, Z Cheng, WM Chen, TJ Lin The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection J. Leukoc. Biol., 2017-10-10;0(0):. 2017-10-10 [PMID: 29018150] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Y Oh, YS Kwon, BD Jung Anti-inflammatory Effects of the Natural Compounds Cortex Phellodendri and Humulus japonicus on Pelvic Inflammatory Disease in Mice Int J Med Sci, 2017-07-18;14(8):729-734. 2017-07-18 [PMID: 28824307] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
SY Nam, KY Kim, MH Kim, JB Jang, SY Rah, HJ Chae, JM Lee, HM Kim, HJ Jeong Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan Pharm Biol, 2017-12-01;55(1):1856-1862. 2017-12-01 [PMID: 28614972] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Yoonsook Kim Oryza sativa (Rice) Hull Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages by Suppressing Extracellular Signal-regulated Kinase, c-Jun N-terminal Kinase, and Nuclear Factor-?B Activation Pharmacogn Mag, 2016-10-01;12(48):295-301. 2016-10-01 [PMID: 27867272] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment Nature Communications 2016-10-25 [PMID: 27779193]
Kim L, Morita R, Kobayashi Y, Eisenbarth S, Lee C, Elias J, Eynon E, Flavell R AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proc Natl Acad Sci U S A, 2015-05-18;112(22):E2891-9. 2015-05-18 [PMID: 26038565] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Lalani A, Moore C, Luo C, Kreider B, Liu Y, Morse H, Xie P Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice. J Immunol, 2014-11-24;194(1):334-48. 2014-11-24 [PMID: 25422508] (ELISA Development, Mouse)	ELISA Development	Mouse
Takato Takenouchi, Shunichi Suzuki, Hiroki Shinkai, Mitsutoshi Tsukimoto, Mitsuru Sato, Hirohide Uenishi et al. Extracellular ATP does not induce P2X7 receptor-dependent responses in cultured renal- and liver-derived swine macrophages Results in Immunology 2014-08-01 [PMID: 25379376]
Bernardo S. Franklin, Lukas Bossaller, Dominic De Nardo, Jacqueline M. Ratter, Andrea Stutz, Gudrun Engels et al. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation Nature Immunology 2014-08-01 [PMID: 24952505]
Ingham V, Williams A, Bate C Glimepiride reduces CD14 expression and cytokine secretion from macrophages. J Neuroinflammation, 2014-06-21;11(0):115. 2014-06-21 [PMID: 24952384] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Bakker P, Butter L, Claessen N, Teske G, Sutterwala F, Florquin S, Leemans J A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion. Am J Pathol, 2014-05-11;184(7):2013-22. 2014-05-11 [PMID: 24823805] (Western Blot, Mouse)	Western Blot	Mouse
Ouyang X, Ghani A, Malik A, Wilder T, Colegio O, Flavell R, Cronstein B, Mehal W Adenosine is required for sustained inflammasome activation via the A(2)A receptor and the HIF-1alpha pathway. Nat Commun, 2013-01-01;4(0):2909. 2013-01-01 [PMID: 24352507] (Western Blot, Mouse)	Western Blot	Mouse
Dominic De Nardo, Larisa I. Labzin, Hajime Kono, Reiko Seki, Susanne V. Schmidt, Marc Beyer et al. High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3 Nature Immunology 2014-02-01 [PMID: 24317040]
Hara , Hideki, Tsuchiya , Kohsuke, Kawamura , Ikuo, Fang , Rendong, Hernandez-Cuellar , Eduardo, Shen , Yanna, Mizuguchi , Junichir, Schweighoffer , Edina, Tybulewicz , Victor, Mitsuyama , Masao Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nat Immunol, 2013-11-03;14(12):1247-55. 2013-11-03 [PMID: 24185614] (Western Blot, Mouse)	Western Blot	Mouse
Junkins R, MacNeil A, Wu Z, McCormick C, Lin T Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol, 2013-04-15;190(10):5178-86. 2013-04-15 [PMID: 23589609] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Shrikant R. Mulay, Onkar P. Kulkarni, Khader V. Rupanagudi, Adriana Migliorini, Murthy N. Darisipudi, Akosua Vilaysane et al. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1 beta secretion Journal of Clinical Investigation 2013-01-02 [PMID: 23221343]
Eisenbarth , Stephani, Williams , Adam, Colegio , Oscar R, Meng , Hailong, Strowig , Till, Rongvaux , Anthony, Henao-Mejia , Jorge, Thaiss , Christop, Joly , Sophie, Gonzalez , David G, Xu , Lan, Zenewicz , Lauren A, Haberman , Ann M, Elinav , Eran, Kleinstein , Steven H, Sutterwala , Fayyaz S, Flavell , Richard NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature, 2012-04-25;484(7395):510-3. 2012-04-25 [PMID: 22538615] (Mouse)		Mouse
Deepak Kumar Kaushik, Malvika Gupta, Kanhaiya Lal Kumawat, Anirban Basu NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis PLoS ONE 2012-02-29 [PMID: 22393394]
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine, 2012-01-25;58(2):169-77. 2012-01-25 [PMID: 22277799] (Luminex Development, Mouse)	Luminex Development	Mouse
Julia Lichtnekert, Onkar P. Kulkarni, Shrikant R. Mulay, Khader Valli Rupanagudi, Mi Ryu, Ramanjaneyulu Allam et al. Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1 PLoS ONE 2011-10-27 [PMID: 22046355]
Linglin Xie, M. Teresa Ortega, Silvia Mora, Stephen K. Chapes Interactive Changes between Macrophages and Adipocytes Clinical and Vaccine Immunology 2010-04-01 [PMID: 20164250]
Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J. Immunol., 2009-10-07;183(9):5799-806. 2009-10-07 [PMID: 19812208] (ELISA Development, Mouse)	ELISA Development	Mouse
Cunha TM, Verri WA, Jr, Fukada SY, Guerrero AT, Santodomingo-Garzon T, Poole S, Parada CA, Ferreira SH, Cunha FQ TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor. Eur. J. Pharmacol., 2007-07-13;573(1):221-9. 2007-07-13 [PMID: 17669394] (ELISA Development, Mouse)	ELISA Development	Mouse
Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm. Res., 2006-11-01;55(11):457-64. 2006-11-01 [PMID: 17122962] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA Development, Mouse)	ELISA Development	Mouse
Ellaban E, Bolgos G, Remick D Selective macrophage suppression during sepsis. Cell. Immunol., 2005-02-26;231(1):103-11. 2005-02-26 [PMID: 15919375] (ELISA Development, Mouse)	ELISA Development	Mouse
Show All 49 Publications. Collapse Publications.

Array BAF401

• IL-1 beta/IL-1F2 Antibodies
• IL-1 beta/IL-1F2 ELISA Kits
• IL-1 beta/IL-1F2 Lysate
• IL-1 beta/IL-1F2 Proteins
• IL-1 beta/IL-1F2 ELISAs
• IL-1 beta/IL-1F2 Proteins and Enzymes