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Human Pro-Cathepsin B Quantikine ELISA Kit

 (9 Publications)
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Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human Pro-Cathepsin B Quantikine ELISA Kit Summary

Background
The Quantikine Human Pro-Cathepsin B Immunoassay is a 4.5 hour solid phase ELISA designed to measure the pro-form of cathepsin B in cell culture supernates, cell lysates, serum, plasma, saliva, and urine. It contains NS0-expressed recombinant human Pro-Cathepsin B and antibodies raised against the recombinant factor. Natural human Pro-Cathepsin B showed dose-response curves that were paralle...l to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative levels of natural human Pro-Cathepsin B.
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Specificity
Natural and recombinant human Pro-Cathepsin B
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CTSB

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DCATB0.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Pro-Cathepsin B Quantikine ELISA Kit

  • APP secretase
  • APPS
  • Cathepsin B
  • Cathepsin B1
  • CPSBamyloid precursor protein secretase
  • CTSB
  • cysteine protease
  • EC 3.4.22
  • EC 3.4.22.1

Background

Cathepsin B is the first described member of the family of lysosomal cysteine proteases. Cathepsin B possesses both endopeptidase and exopeptidase activities, in the latter case acting as a peptidyl-dipeptidase. It is known to process a number of proteins, including pro and active caspases, prorenin and SLPI. Cathepsin B is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Cathepsin B (DCATB0)(9)

We have publications tested in 1 confirmed species: Human.


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Human
(9)
All Species
Showing Publications 1 - 9 of 9.
Publications using DCATB0 Applications Species
Rodriguez-Franco EJ, Cantres-Rosario YM, Plaud-Valentin M, Romeu R, Rodriguez Y, Skolasky R, Melendez V, Cadilla CL, Melendez LM Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. PLoS ONE, 2012-05-31;7(5):e36571. 2012-05-31 [PMID: 22693552] (Human) Human
Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis. PLoS ONE, 2012-02-23;7(2):e32272. 2012-02-23 [PMID: 22384200] (Human) Human
Chang KP, Wu CC, Chen HC Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: potential usage of cystatin A for predicting nodal stage and poor prognosis. Proteomics, 2010-07-01;10(14):2644-60. 2010-07-01 [PMID: 20461718] (Human) Human
Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy R, Jay GD Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum., 2008-06-01;58(6):1707-15. 2008-06-01 [PMID: 18512776] (Human) Human
Tsai HT, Wang PH, Tee YT, Lin LY, Hsieh YS, Yang SF Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease. Fertil. Steril., 2008-03-07;91(2):549-55. 2008-03-07 [PMID: 18314113] (Human) Human
Potapova IA, Gaudette GR, Brink PR, Robinson RB, Rosen MR, Cohen IS, Doronin SV Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro. Stem Cells, 2007-03-29;25(7):1761-8. 2007-03-29 [PMID: 17395769] (Human) Human
Ma DH, Yao JY, Kuo MT, See LC, Lin KY, Chen SC, Chen JK, Chao AS, Wang SF, Lin KK Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane. Invest. Ophthalmol. Vis. Sci., 2007-02-01;48(2):644-51. 2007-02-01 [PMID: 17251461] (Human) Human
Rofstad EK, Mathiesen B, Kindem K, Galappathi K Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res., 2006-07-01;66(13):6699-707. 2006-07-01 [PMID: 16818644] (Human) Human
Miyake H, Hara I, Eto H Serum level of cathepsin B and its density in men with prostate cancer as novel markers of disease progression. Anticancer Res., 2004-07-01;24(4):2573-7. 2004-07-01 [PMID: 15330217] (Human) Human

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Bioinformatics

Gene Symbol CTSB