Human CXCL5/ENA-78 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCL5/Epithelial Cell-derived Neutrophil-activating Peptide (ENA-78), is a member of the CXC subfamily of chemokines. Full-length CXCL5/ENA-78 is 114 amino acids (aa) in length with a predicted molecular weight of 12 kDa. Following the removal of the signal peptide, bioactive CXCL5/ENA-78 is 78 aa in length. CXCL5/ENA-78 can be N-terminally cleaved by Cathepsin G and Chymotrypsin to CXCL5/ENA-74 (74 aa) and CXCL5/ENA-70 (70 aa), which show increased potency relative to CXCL5/ENA-78. While murine LIX was thought to be an ortholog to human CXCL5/ENA-78, genome-wide analysis and a consensus in the field suggests that human CXCL5/ENA-78 does not have a true murine ortholog. CXCL5/ENA-78 is upregulated at sites of inflammation and is expressed by multiple hematopoietic cell types, fibroblasts, endothelial cells, vascular smooth muscle cells, and adipocytes. It acts as a chemoattractant for neutrophils, has angiogenic properties, and contributes to cancer progression.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using DX000	Applications	Species
Zhou, J;Xu, W;Wu, Y;Wang, M;Zhang, N;Wang, L;Feng, Y;Zhang, T;Wang, L;Mao, A; GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway Oncogene 2023-09-25 [PMID: 37749229] (Human)		Human
Chen, C;Lin, LY;Chen, JW;Chang, TT; CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus Cardiovascular diabetology 2023-07-07 [PMID: 37420254] (Human)		Human
G Xiao, R Kumar, Y Komuro, J Burguet, V Kakarla, I Azizkhania, SA Sheth, CK Williams, XR Zhang, M Macknicki, A Brumm, R Kawaguchi, P Mai, N Kaneko, HV Vinters, ST Carmichael, LA Havton, C DeCarli, JD Hinman IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury Cell Reports, 2022-12-20;41(12):111848. 2022-12-20 [PMID: 36543124] (Human)		Human
C Sorrentino, L D'Antonio, SL Ciummo, C Fieni, L Landuzzi, F Ruzzi, S Vespa, P Lanuti, LV Lotti, PL Lollini, E Di Carlo CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality Journal of hematology & oncology, 2022-10-13;15(1):145. 2022-10-13 [PMID: 36224639] (Human)		Human
T Wu, W Wang, G Shi, M Hao, Y Wang, M Yao, Y Huang, L Du, X Zhang, D Ye, X Bian, J Wang Targeting HIC1/TGF-beta axis-shaped prostate cancer microenvironment restrains its progression Cell Death & Disease, 2022-07-19;13(7):624. 2022-07-19 [PMID: 35853880] (Human)		Human
N Lin, L Chen, Y Zhang, Y Yang, L Zhang, L Chen, P Zhang, H Su, M Yin KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment Scientific Reports, 2022-04-10;12(1):6015. 2022-04-10 [PMID: 35399116] (Human)		Human
L Kobari, M Auclair, O Piau, N Ferrand, M Zaoui, F Delhommeau, B Fève, M Sabbah, L Garderet Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells Leukemia, 2021-09-23;0(0):. 2021-09-23 [PMID: 34556797] (Human)		Human
KH Tsui, KS Chang, HC Sung, SY Hsu, YH Lin, CP Hou, PS Yang, CL Chen, TH Feng, HH Juang Mucosa-Associated Lymphoid Tissue 1 Is an Oncogene Inducing Cell Proliferation, Invasion, and Tumor Growth via the Upregulation of NF-&kapppaB Activity in Human Prostate Carcinoma Cells Biomedicines, 2021-03-03;9(3):. 2021-03-03 [PMID: 33802402] (Human)		Human
Y Ando, K Ohuchida, Y Otsubo, S Kibe, S Takesue, T Abe, C Iwamoto, K Shindo, T Moriyama, K Nakata, Y Miyasaka, T Ohtsuka, Y Oda, M Nakamura Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5 PLoS ONE, 2020-01-30;15(1):e0228015. 2020-01-30 [PMID: 31999765] (Human)		Human
E Flaherty, S Zhu, N Barretto, E Cheng, PJM Deans, MB Fernando, N Schrode, N Francoeur, A Antoine, K Alganem, M Halpern, G Deikus, H Shah, M Fitzgerald, I Ladran, P Gochman, J Rapoport, NM Tsankova, R McCullumsm, GE Hoffman, R Sebra, G Fang, KJ Brennand Neuronal impact of patient-specific aberrant NRXN1alpha splicing Nat. Genet., 2019-11-29;51(12):1679-1690. 2019-11-29 [PMID: 31784728] (Human)		Human
L Fong, A Hotson, J Powderly, M Sznol, RS Heist, TK Choueiri, S George, BG Hughes, MD Hellmann, DR Shepard, BI Rini, S Kummar, AM Weise, MJ Riese, B Markman, LA Emens, D Mahadevan, JJ Luke, G Laport, JD Brody, L Hernandez-, P Bonomi, JW Goldman, L Berim, DJ Renouf, RA Goodwin, B Munneke, PY Ho, J Hsieh, I McCaffery, L Kwei, SB Willingham, RA Miller Adenosine A2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer Cancer Discov, 2019-11-15;0(0):. 2019-11-15 [PMID: 31732494] (Human)		Human
W Liu, P Wang, Z Xie, S Wang, M Ma, J Li, M Li, S Cen, S Tang, G Zheng, G Ye, X Wu, Y Wu, H Shen Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis Cell Death Dis, 2019-02-25;10(3):188. 2019-02-25 [PMID: 30804325] (Human)		Human
M Taki, K Abiko, T Baba, J Hamanishi, K Yamaguchi, R Murakami, K Yamanoi, N Horikawa, Y Hosoe, E Nakamura, A Sugiyama, M Mandai, I Konishi, N Matsumura Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation Nat Commun, 2018-04-27;9(1):1685. 2018-04-27 [PMID: 29703902] (Human)		Human
WZ Qiu, HB Zhang, WX Xia, LR Ke, J Yang, YH Yu, H Liang, XJ Huang, GY Liu, WZ Li, YQ Xiang, TB Kang, X Guo, X Lv The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3?/snail signalling J. Exp. Clin. Cancer Res., 2018-04-17;37(1):85. 2018-04-17 [PMID: 29665837] (Human)		Human
Li-Ming Lu Neutrophil infiltration mediated by CXCL5 accumulation in the laryngeal squamous cell carcinoma microenvironment: A mechanism by which tumour cells escape immune surveillance Clin. Immunol., 2016-11-19;175(0):34-40. 2016-11-19 [PMID: 27876461] (Human)		Human
Tzeng , Tsai-Ten, Tsay , Huey-Jen, Chang , Luping, Hsu , Chia-Lin, Lai , Tzu-Hsua, Huang , Fong-Lee, Shiao , Young-Ji Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid. J Biomed Sci, 2013-12-06;20(0):90. 2013-12-06 [PMID: 24313976] (Human)		Human
Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura. J. Thromb. Haemost., 2012-08-01;10(8):1616-23. 2012-08-01 [PMID: 22537155] (Human)		Human
Sung SY, Hsieh CL, Law A, Zhau HE, Pathak S, Multani AS, Lim S, Coleman IM, Wu LC, Figg WD, Dahut WL, Nelson P, Lee JK, Amin MB, Lyles R, Johnstone PA, Marshall FF, Chung LW Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis. Cancer Res., 2008-12-01;68(23):9996-10003. 2008-12-01 [PMID: 19047182] (Human)		Human
Lee YR, Kweon SH, Kwon KB, Park JW, Yoon TR, Park BH Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes. Biochem. Biophys. Res. Commun., 2008-11-11;378(1):90-4. 2008-11-11 [PMID: 19007749] (Human)		Human
Skov L, Beurskens FJ, Zachariae CO, Reitamo S, Teeling J, Satijn D, Knudsen KM, Boot EP, Hudson D, Baadsgaard O, Parren PW, van de Winkel JG IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis. J. Immunol., 2008-07-01;181(1):669-79. 2008-07-01 [PMID: 18566434] (Human)		Human
Lee SJ, Nam WD, Na HJ, Cho YL, Ha KS, Hwang JY, Lee H, Kim SO, Kwon YG, Kim YM CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation. Biochem. Pharmacol., 2008-04-18;76(1):79-90. 2008-04-18 [PMID: 18513703] (Human)		Human
Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. Life Sci., 2008-04-20;82(23):1203-9. 2008-04-20 [PMID: 18495175] (Human)		Human
Flanagan K, Modrusan Z, Cornelius J, Chavali A, Kasman I, Komuves L, Mo L, Diehl L Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion. J. Immunol., 2008-03-15;180(6):3874-81. 2008-03-15 [PMID: 18322195] (Mouse)		Mouse
Matsuda A, Fukuda S, Matsumoto K, Saito H Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesis. Am. J. Respir. Cell Mol. Biol., 2007-08-20;38(2):168-75. 2007-08-20 [PMID: 17709600] (Human)		Human
Newcomb DC, Sajjan US, Nagarkar DR, Goldsmith AM, Bentley JK, Hershenson MB Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-07-13;293(4):L1021-8. 2007-07-13 [PMID: 17631613] (Human)		Human
Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J. Clin. Invest., 2007-07-01;117(7):1951-60. 2007-07-01 [PMID: 17557119] (Human)		Human
Dimberg J, Dienus O, Lofgren S, Hugander A, Wagsater D Expression and gene polymorphisms of the chemokine CXCL5 in colorectal cancer patients. Int. J. Oncol., 2007-07-01;31(1):97-102. 2007-07-01 [PMID: 17549409] (Human)		Human
Antoniou KM, Tzouvelekis A, Alexandrakis MG, Sfiridaki K, Tsiligianni I, Rachiotis G, Tzanakis N, Bouros D, Milic-Emili J, Siafakas NM Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis. Chest, 2006-10-01;130(4):982-8. 2006-10-01 [PMID: 17035428] (Human)		Human
Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis, 2006-10-04;192(1):56-66. 2006-10-04 [PMID: 17022986] (Human)		Human
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol., 2005-11-01;175(9):6177-89. 2005-11-01 [PMID: 16237115] (Human)		Human
Gessler P, Pretre R, Hohl V, Rousson V, Fischer J, Dahinden C CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery. Shock, 2004-12-01;22(6):513-20. 2004-12-01 [PMID: 15545821] (Human)		Human
Suzumori N, Katano K, Suzumori K Peritoneal fluid concentrations of epithelial neutrophil-activating peptide-78 correlate with the severity of endometriosis. Fertil. Steril., 2004-02-01;81(2):305-8. 2004-02-01 [PMID: 14967364] (Human)		Human
Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O'Reilly RJ, Dupont B, Vyas YM Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J. Immunol., 2003-12-15;171(12):6891-9. 2003-12-15 [PMID: 14662896] (Human)		Human
Maheshwari A, Christensen RD, Calhoun DA ELR+ CXC chemokines in human milk. Cytokine, 2003-11-07;24(3):91-102. 2003-11-07 [PMID: 14581003] (Human)		Human
Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion. Eur. J. Immunol., 2002-07-01;32(7):2037-45. 2002-07-01 [PMID: 12115625] (Human)		Human
Show All 35 Publications. Collapse Publications.

Array DX000

• CXCL5/ENA-78 Antibodies
• CXCL5/ENA-78 Antibody Pair
• CXCL5/ENA-78 ELISA Kits
• CXCL5/ENA-78 Lysate
• CXCL5/ENA-78 Proteins
• CXCL5/ENA-78 Proteins and Enzymes
• CXCL5/ENA-78 ELISAs