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Gelsolin/GSN Antibody (20) [DyLight 550]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clone
20
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 550

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-05161AF350
Alexa Fluor 405
NBP1-05161AF405
Alexa Fluor 488
NBP1-05161AF488
Alexa Fluor 532
NBP1-05161AF532
Alexa Fluor 594
NBP1-05161AF594
Alexa Fluor 647
NBP1-05161AF647
Alexa Fluor 700
NBP1-05161AF700
Alexa Fluor 750
NBP1-05161AF750
Biotin
NBP1-05161B
CoraFluor 1
NBP1-05161CL1
DyLight 350
NBP1-05161UV
DyLight 405
NBP1-05161V
DyLight 488
NBP1-05161G
DyLight 594
NBP1-05161DL594
DyLight 650
NBP1-05161C
DyLight 680
NBP1-05161FR
DyLight 755
NBP1-05161IR
FITC
NBP1-05161F
HRP
NBP1-05161H
Janelia Fluor 525
NBP1-05161JF525
Janelia Fluor 549
NBP1-05161JF549
Janelia Fluor 585
NBP1-05161JF585
Janelia Fluor 635
NBP1-05161JF635
Janelia Fluor 646
NBP1-05161JF646
Janelia Fluor 669
NBP1-05161JF669
Unconjugated
NBP1-05161
mFluor Violet 450 SE
NBP1-05161MFV450
mFluor Violet 500 SE
NBP1-05161MFV500
mFluor Violet 610 SE
NBP1-05161MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-05161
BSA Free
NBP1-05161-0.025mg
BSA Free
NBP1-05161
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Gelsolin/GSN Antibody (20) [DyLight 550] Summary

Immunogen
Gelsolin purified from human plasma
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
GSN
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Gelsolin/GSN Antibody (20) [DyLight 550]

  • Actin-depolymerizing factor
  • ADF
  • AGEL
  • Brevin
  • DKFZp313L0718
  • gelsolin (amyloidosis, Finnish type)
  • Gelsolin
  • GSN

Background

Gelsolin is a calcium regulated actin binding protein. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol GSN