D4-GDI/RhoGDI2 Antibody (10D774) [Biotin]

D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-55788	Applications	Species
Lee SH, Lee JW, Kim HS et al. Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer APMIS 2003-05-01 [PMID: 12887511] Details: This citation used the Biotin version of this antibody.

Array NB100-55788

• D4-GDI/RhoGDI2 Antibodies
• D4-GDI/RhoGDI2 ELISA Kits
• D4-GDI/RhoGDI2 Lysate
• D4-GDI/RhoGDI2 Proteins