Chymotrypsin C/CTRC Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Chymotrypsin C (CTRC), also known as caldecrin, is a serine protease and a member of the peptidase S1 family. The CTRC gene encodes a serum calcium-decreasing factor that has chymotrypsin-like protease activity (1). CTRC has broad substrate specificity, but prefers to cleave on the carboxyl side of hydrophobic residues. The enzyme is expressed primarily in the pancreas, and is secreted into the digestive tract. CTRC is a key regulator of activation and degradation of cationic trypsinogen (2, 3). The inappropriate activation of cationic trypsinogen can contribute to the development of pancreatitis (2, 3). CTRC inhibits osteoclast differentiation by suppression of NFATc1 function by a mechanism independent of its proteolytic activity (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using AF6907	Applications	Species
A Geisz, Z Jancsó, BC Németh, E Hegyi, M Sahin-Tóth Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice JCI Insight, 2019-06-18;5(0):. 2019-06-18 [PMID: 31211695] (Western Blot, Mouse)	Western Blot	Mouse

Array AF6907

• Chymotrypsin C/CTRC Antibodies
• Chymotrypsin C/CTRC ELISA Kits
• Chymotrypsin C/CTRC Lysate
• Chymotrypsin C/CTRC Protein
• Chymotrypsin C/CTRC Proteins and Enzyme