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CD94 Antibody (131412) [Phycoerythrin]

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Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD94 PE-conjugated Monoclonal Antibody (Catalog # FAB1058P) and Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
131412
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

Order Details

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CD94 Antibody (131412) [Phycoerythrin] Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human CD94 and NKG2A
Specificity
Recognizes human CD94 both in its homodimeric form and as a heterodimer with either NKG2A or NKG2C.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KLRD1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD94 Antibody (131412) [Phycoerythrin]

  • CD94 antigen
  • CD94
  • CD94natural killer cells antigen CD94
  • Killer cell lectin-like receptor subfamily D member 1
  • killer cell lectin-like receptor subfamily D, member 1
  • KLRD1
  • KP43
  • NK cell receptor

Background

CD94, also known as KLAD1, is a 30 kDa type II transmembrane protein with an extracellular C-type lectin domain. It is expressed by natural killer (NK) cells and a subset of CD8+ T cells, with cellular activation resulting in increased cell surface expression. Although CD94 can occur as a non-signaling homodimer, functional activity occurs when CD94 exists as a heterodimer with an NKG2 family member. A CD94/NKG2A heterodimer delivers an inhibitory signal to the expressing cell, whereas, a CD94/NKG2C heterodimer associates with the DAP12 adapter protein and delivers an activating signal. Both heterodimeric complexes recognize HLA-E with an associated peptide derived from the signal peptide of other HLA proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KLRD1