Human CD3 epsilon ELISA Kit (Colorimetric)

CD3 epsilon is a subunit of CD3. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA.

Showing Publication 1 - 1 of 1.

Publication using NBP2-75143	Applications	Species
Takahashi H, KUhtreiber WM, Keefe RC et al. BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes Science advances 2022-11-18 [PMID: 36383663] (ELISA, Human)	ELISA	Human

Array NBP2-75143

• CD3 epsilon Antibodies
• CD3 epsilon ELISA Kit
• CD3 epsilon Lysate
• CD3 epsilon Proteins
• CD3 epsilon Proteins and Enzyme