CCL2/MCP1 Antibody (2D8) - BSA Free

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Feline.

We have publications tested in 9 applications: Block/Neutralize, ICC/IF, IF/IHC, IHC, IHC-P, Knockdown Validated, SPR, WB, Western Blot.

Showing Publications 1 - 10 of 29. Show All 29 Publications. Collapse Publications.

Publications using NBP2-22115	Applications	Species
Wang C, Cheng F, Han Z, Yan B et Al. Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis Neural Regen Res 2024-05-31 [PMID: 38819064]
Suzuki K, Ohe R, Kabasawa T et al. Histological spatial analysis on the induction of PD-L1+ macrophages by CD8+ T cells at the marginal microenvironment of triple-negative breast cancer Breast cancer (Tokyo, Japan) 2023-11-01 [PMID: 37792212] (IHC, Human)	IHC	Human
Huang W, Hong S, Zhu X et al. Obesity Blunts the Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicles Kidney International Reports 2023-06-21 [PMID: 37705914] (Block/Neutralize)	Block/Neutralize
Cui Y, Wang X, Xu Y et al. Ropivacaine promotes axon regeneration by regulating Nav1.8-mediated macrophage signaling after sciatic nerve injury in rats Anesthesiology 2023-09-05 [PMID: 37669448] (WB, Rat)	WB	Rat
Xu Z, Wang X, Kuang W et al. Kaempferol improves acute kidney injury via inhibition of macrophage infiltration in septic mice Bioscience Reports 2023-07-26 [PMID: 37440431] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Aamir K, Sethi G, Afrin MR et al. Arjunolic acid modulate pancreatic dysfunction by ameliorating pattern recognition receptor and canonical Wnt pathway activation in type 2 diabetic rats Life sciences 2023-08-15 [PMID: 37307966]
Bae J, Lee JY, Shin E et al. The effects of the voglibose on non-alcoholic fatty liver disease in mice model Scientific reports 2022-08-10 [PMID: 35948569] (WB, Mouse)	WB	Mouse
Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding, S Zheng, N Yang, Z Zhang, L Li, L Tan, H Song, J Fu Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis Cell Death & Disease, 2022-05-31;13(5):512. 2022-05-31 [PMID: 35641492]
Guo X, Guo Y, Wang Z et al. Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis Oxidative medicine and cellular longevity 2022-03-29 [PMID: 35391927] (WB, IF/IHC, Mouse, Human)	WB, IF/IHC	Mouse, Human
Go RE, Lee SM, Shin yJ et al. Time-dependent effect of inhaled cigarette smoke exposure in the bleomycin-induced lung injury rat model Environmental toxicology 2022-02-03 [PMID: 35112775]
Dajnoki Z, Somogyi O, Medgyesi B Et al. Primary alterations during the development of hidradenitis suppurativa Journal of the European Academy of Dermatology and Venereology : JEADV 2021-11-01 [PMID: 34724272]
BL Phipps, U Suwannasua, J Lucero, NA Mitchell, AK Lund Vehicle emissions-exposure alters expression of systemic and tissue-specific components of the renin-angiotensin system and promotes outcomes associated with cardiovascular disease and obesity in wild-type C57BL/6 male mice Toxicology reports, 2021-04-15;8(0):846-862. 2021-04-15 [PMID: 33948438]
Upmanyu N, Bulldan A, Failing K, Scheiner-Bobis G DHEAS prevents pro-metastatic and proliferative effects of 17 beta-estradiol on MCF-7 breast cancer cells Biochim Biophys Acta Mol Cell Res 2019-11-21 [PMID: 31760088] (ICC/IF, Human)	ICC/IF	Human
Pasupulati A, Nishad R, Mukhi D et al. Growth hormone induces TNF-alpha in podocytes and contributes to monocyte-to-macrophage differentiation: Implications in Diabetic kidney disease Research Square 2022-02-02
Sorrentino G, Rezakhani S, Yildiz E et al. Mechano-modulatory synthetic niches for liver organoid derivation Nat Commun 2020-07-10 [PMID: 32651372] (WB, Mouse, Human)	WB	Mouse, Human
Wenstedt EF, Verberk SG, Kroon J, et al. Salt increases monocyte CCR2 expression and inflammatory responses in humans JCI Insight 2019-11-01 [PMID: 31672939] (IHC-P, Human)	IHC-P	Human
Wolf M, Clay S. M, et al. MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2. Sci Rep 2019-08-09 [PMID: 31399604] (IF/IHC, Mouse)	IF/IHC	Mouse
Pascual-Garcia M, Bonfill-Teixidor E, Planas-Rigol E et al. LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy Nat Commun 2019-06-11 [PMID: 31186412] (ICC/IF, IF/IHC, Human, Mouse)	ICC/IF, IF/IHC	Human, Mouse
Do C, Drel V, Tan C, Lee D et al. Nephrogenic' systemic fibrosis is mediated by myeloid C-C chemokine receptor 2 J. Invest. Dermatol. 2019-04-09 [PMID: 30978353]
Rojo JL, Jaworski JP, Peluffo MC. Direct role of the C-C motif chemokine receptor 2/monocyte chemoattractant protein 1 system in the feline cumulus oocyte complex. Biol. Reprod. 2018-11-03 [PMID: 30395163] (ICC/IF, Feline)	ICC/IF	Feline
Beke G, Dajnoki Z, Kapitany A et al. Immunotopographical Differences of Human Skin. Front Immunol. 2018-03-05 [PMID: 29556238] (IHC-P, Human)	IHC-P	Human
Garzia L, Kijima N, Morrissy AS, De Antonellis P. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018-02-22 [PMID: 29474906] (Western Blot, Knockdown Validated)	Western Blot, Knockdown Validated
Linde N, Casanova-Acebes M, Sosa MS et al. Macrophages orchestrate breast cancer early dissemination and metastasis Nat Commun 2018-01-02 [PMID: 29295986] (IHC-P, Mouse)	IHC-P	Mouse
Zhi LQ, Yao SX, Liu HL et al. Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy. Mol Med Rep 2018-03-01 [PMID: 29286133] (Rat)		Rat
Kuwahara G, Hashimoto T, Tsuneki M et al. CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arterioscler. Thromb. Vasc. Biol. 2017-06-01 [PMID: 28450292] (Mouse)		Mouse
Nishio M, Sugimachi K, Goto H et al. Dysregulated YAP1/TAZ and TGF-b signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 2016-01-05 [PMID: 26699479] (WB, Mouse)	WB	Mouse
Chen S, Jiao J, Jiang D et al. T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines Tumour Biol. 2015-03-06 [PMID: 25744730] (Human)		Human
Quimbaya P, Garzon V, Bustos R et al. Real-time quantification of proteins secreted of conditioned media from mesenchymal stromal cells (MSC) in co-culture with hematopoietic progenitor cells Sensing and Bio-Sensing Research 2023-11-01 (SPR, Human)	SPR	Human
Yamamoto S, Zhong J, Yancey PG et al. Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype Atherosclerosis. 2015-07-04 [PMID: 26184694] (IHC-P, Mouse)	IHC-P	Mouse
Show All 29 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	IHC-P	Rhesus Macaque	11/25/2019	View Summary Application Immunohistochemistry-Paraffin Sample Tested HIV-infected Rhesus macaque adult lung Species Rhesus Macaque Lot A-7 Comments Comments Heat-mediated Antigen Retrieval with 10mM Na Citrate buffer, pH6.0. Block with 5% Normal Goat Serum in PBS for 30min, RT Primary antibody (MCP-1, 1:500 dilution) overnight, 4 C HRP-conjugated 2nd antibody (1:500) for 30min, RT DAB staining Countersigning with hematoxylin

Array NBP2-22115

• CCL2/MCP1 Antibodies
• CCL2/MCP1 ELISA Kits
• CCL2/MCP1 Lysate
• CCL2/MCP1 Proteins