The Quantikine Canine IL-8 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure canine IL-8 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant canine IL-8 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural canine IL-8 sho...wed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring canine IL-8.
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Specificity
Natural and recombinant canine IL-8. This assay also recognizes the 74 and 79 amino acid variants of recombinant canine IL-8.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Canine IL-8/CXCL8 Quantikine ELISA Kit
3-10C
AMCF-I
C-X-C motif chemokine 8
CXCL8
CXCL8SCYB8
Emoctakin
GCP1
GCP-1TSG-1
IL8
IL-8
interleukin 8
K60
LAI
LECT
LUCT
LYNAP
MDNCF
MDNCFb-ENAP
member 8
MONAP
MONAPGCP1
NAF
NAP1
NAP-1NAP1
NCF
Neutrophil-activating protein 1
Protein 3-10C
T cell chemotactic factor
T-cell chemotactic factor
TCF
TSG1
Background
Interleukin-8 (IL-8), also known as CXCL8, is a chemokine that is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. IL-8 can form homodimers and heterodimers with CXCL4/PF4. Its bioactivity is regulated by proteolytic truncations, citrullination, and the decoy receptor DARC. IL-8 signals through CXCR1/IL-8 RA, which is also used by CXCL6, and through CXCR2/IL-8 RB, which is used by multiple CXC chemokines. IL-8 also binds to Serpin A1/alpha-1 Antitrypsin which prevents IL-8 interaction with CXCR1.
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
Publications for CXCL8/IL-8 (CA8000)(5)
We have publications tested in 1 confirmed species: Canine.