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Bone marrow stromal cell antigen 1/CD157 Antibody (534509) [Unconjugated]

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Human peripheral blood granulocytes were stained with Mouse Anti-Human CD157 Monoclonal Antibody (Catalog # MAB47361, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).
Human peripheral blood granulocytes were stained with Mouse Anti-Human CD157 Monoclonal Antibody (Catalog # MAB47361, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, CyTOF-ready
Clone
534509
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB47361U-100UG
Alexa Fluor 405
FAB47361V-100UG
Alexa Fluor 488
FAB47361G-100UG
Alexa Fluor 532
FAB47361X
Alexa Fluor 594
FAB47361T-100UG
Alexa Fluor 647
FAB47361R-100UG
Alexa Fluor 700
FAB47361N-100UG
Alexa Fluor 750
FAB47361S-100UG
Allophycocyanin
FAB47361A
Allophycocyanin/Cy7
FAB47361APCCY7
Biotin
FAB47361B
CoraFluor 1
FAB47361CL1
DyLight 350
FAB47361D
DyLight 405
FAB47361E
DyLight 488
FAB47361K
DyLight 550
FAB47361L
DyLight 594
FAB47361M
DyLight 650
FAB47361W
DyLight 680
FAB47361Y
DyLight 755
FAB47361Z
FITC
FAB47361F
HRP
FAB47361H
Janelia Fluor 525
FAB47361JF525
Janelia Fluor 549
FAB47361I
Janelia Fluor 585
FAB47361JF585
Janelia Fluor 635
FAB47361JF635
Janelia Fluor 646
FAB47361J
Janelia Fluor 669
FAB47361JF669
PE
FAB47361P
PE/Atto594
FAB47361PEATT594
PE/Cy5.5
FAB47361PECY55
PE/Cy7
FAB47361PECY7
PerCP
FAB47361C
mFluor Violet 450 SE
FAB47361MFV450
mFluor Violet 500 SE
FAB47361MFV500
mFluor Violet 610 SE
FAB47361MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB47361-SP
Carrier Free
FAB47361V-100UG
Carrier Free
FAB47361U-100UG
Carrier Free
FAB47361T-100UG
Carrier Free
FAB47361S-100UG
Carrier Free
FAB47361R-100UG
Carrier Free
FAB47361N-100UG
Carrier Free
FAB47361G-100UG
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Bone marrow stromal cell antigen 1/CD157 Antibody (534509) [Unconjugated] Summary

Immunogen
NS0 mouse myeloma cell line transfected with human CD157
Gly29-Lys292
Accession # Q10588
Specificity
Detects human CD157 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BST1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA
  • Flow Cytometry 0.25 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Bone marrow stromal cell antigen 1/CD157 Antibody (534509) [Unconjugated]

  • ADP-ribosyl cyclase 2
  • Bone marrow stromal antigen 1
  • bone marrow stromal cell antigen 1
  • BP-3
  • BST1
  • BST-1
  • cADPr hydrolase 2
  • CD157 antigen
  • CD157
  • Cyclic ADP-ribose hydrolase 2
  • EC 3.2.2.5
  • NAD(+) nucleosidase

Background

CD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST-1), is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family (1). CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth (2, 3). Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities (2). It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in
RA-derived bone marrow stromal cell lines (3). CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule (4).

  1. Hussain, A. M. M. et al. (1998) Protein Express. Purif. 12:133.
  2. Sato, A. et al. (1999) Biochem. J. 337:491.
  3. Kaisho, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91:5325.
  4. Ortolan, E. et al. (2002) Cell Biochem. Funct. 20:309.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bone marrow stromal cell antigen 1/CD157 Antibody (534509) [Unconjugated]
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Bioinformatics

Gene Symbol BST1
Uniprot