| Reactivity | HuSpecies Glossary |
| Applications | WB, IP |
| Clonality | Polyclonal |
| Host | Sheep |
| Conjugate | Unconjugated |
| Concentration | LYOPH |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human ADAM23 Ser60-His585 Accession # O75077 |
| Specificity | Detects human ADAM23 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) ADAM8, rhADAM9, and rhADAM22 is observed. |
| Source | N/A |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Sheep |
| Gene | ADAM23 |
| Purity Statement | Antigen Affinity-purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative | No Preservative |
| Concentration | LYOPH |
| Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
ADAM23 (a disintegrin and metalloprotease domain 23; also MDC3) is a 100 kDa member of the M12B peptidase family of enzymes. It is expressed on fetal neurons in the hippocampus and cerebellum and serves as a counter‑receptor for alpha v beta 3 integrin. The human ADAM23 proprecursor is a 773 amino acid (aa) type I transmembrane (TM) protein. It contains a 227 aa cleavable proregion (aa 60‑286) and a 506 aa extracellular domain (ECD) (aa 287‑792) that is part of a 70 kDa mature molecule. The ECD contains a nonfunctional metalloprotease domain (aa 299‑494), an integrin‑binding disintegrin region (aa 511‑585) and a Cys‑rich domain (aa 589‑611). Two splice variants exist. One shows an in‑frame 46 aa substitution for aa 787‑832 that generates a soluble form, while a second shows an in‑frame 31 aa TM substitution for aa 787‑817. Over aa 1‑585, human ADAM23 is 92% aa identical to mouse ADAM23.
![Western Blot ADAM22 Antibody (498805) [Unconjugated]](https://images.novusbio.com/images2/ADAM22_MAB49081_Western_Blot_6213.jpg)
Secondary Antibodies |
Isotype Controls |
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
![Knockout Validated ADAM9 Antibody [Unconjugated]](https://images.novusbio.com/images2/ADAM9_AF949_Knockout_Validated_22788.jpg)
![Western Blot ADAM9 Antibody [Unconjugated]](https://images.novusbio.com/images2/ADAM9_AF949_Western_Blot_20484.jpg)
![Western Blot ADAM9 Antibody [Unconjugated]](https://images.novusbio.com/images/af949_human-mouse-adam9-ectodomain-affinity-purified-polyclonal-ab-8220249503224.jpg)
![ADAM10 [Unconjugated]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "ADAM10 [Unconjugated]")
![N/A CCL22/MDC [HRP]](https://images.novusbio.com/images2/CCL22_DMD00_ELISA_142.jpg)
![N/A CCL22/MDC [HRP]](https://images.novusbio.com/images2/DATA_CCL22_DMD00_ELISA_762.jpg)
