5-HT3A Antibody

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-41382	Applications	Species
Wang J, Mei Y, Zhang X et al. Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer's disease Cell reports 2023-02-22 [PMID: 36821438] (WB, Mouse) Details: Dilution used in IHC-FrFl 1:500	WB	Mouse
Lee SO, Abdelrahim M, Yoon K et al. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Res. 2010-09-01 [PMID: 20660371] (WB) Details: HTR3A (IMG-30127) and SP1 (IMG-3860). WB: Endogenous p300 was immunoprecipitated with anti-p300 antibodies and the resulting immunoprecipitates were analyzed by WB using the Sp1 antibody (IMG-3860), Fig 6C. WB: Nuclear extracts from Panc1 cells were subject to WB with the TR3 and Sp1 antibody, Fig 5D. WB: Panc1 cells treated with Sp1 siRNA, Fig 4D. WB: Panc1 cells treated with TR3 siRNA, Fig 1D.Note: The Sp1 and TR3 antibodies was siRNA validated by WB in Panc1 cells, Figs 1D & 4D, respectively.	WB
Lu CL, Hsieh JC, Dun NJ et al. Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats. Gastroenterology 2009-09-01 [PMID: 19344720]
Dremencov E, Weizmann Y, Kinor N et al. Modulation of dopamine transmission by 5HT2C and 5HT3 receptors: a role in the antidepressant response. Curr Drug Targets 2006-02-01 [PMID: 16475958]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Renee Ryals	IHC-Fr	Mouse	03/03/2015	View Summary Application Immunohistochemistry-Frozen Sample Tested C57BL/6 mouse retina Species Mouse Lot P1N110712

Array NB100-41382

• 5-HT3A Antibodies
• 5-HT3A Lysates
• 5-HT3A Protein