5-HT1B Antibody (499325)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
499325
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

5-HT1B Antibody (499325) Summary

Immunogen
NS0 mouse myeloma cell line transfected with human 5HT1B
Met1-Ser390
Accession # P28222
Specificity
Detects human 5HT1B.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
HTR1B
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
Publications
Read Publication using MAB5858.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 5-HT1B Antibody (499325)

  • 5HT1B
  • 5-HT1B
  • 5-HT1B5-HT-1B
  • 5HT1DB
  • 5-HT1DB
  • 5-hydroxytryptamine (serotonin) receptor 1B
  • HTR1B
  • HTR1D2
  • HTR1D2,5-hydroxytryptamine receptor 1B
  • HTR1DB
  • S12
  • S125-HT-1D-beta
  • Serotonin 1D beta receptor
  • Serotonin receptor 1B

Background

5HT1B is a 7TM receptor for serotonin and is expressed on striatal neurons and Purkinje cells in the cerebellum. 5HT1B ligation inhibits glycinergic signaling, appetite, circadian rhythm light responsiveness, and trigeminal-mediated nociception. It is an important pharmacologic target in the treatment of migrane headaches. Human 5HT1B shares 92% aa sequence identity with mouse and rat 5HT1B.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for 5-HT1B Antibody (MAB5858)(1)

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Bioinformatics

Gene Symbol HTR1B
Uniprot