TEP1 Products

Description

Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Bioinformatics

Entrez	21745 Mouse 64523 Rat 7011 Human
Uniprot	AAC51107 Human NP_009041 Human Q99973 Human
Product By Gene ID	7011
Alternate Names	p240telomerase protein component 1 telomerase-associated protein 1VAULT2 TLP1p80 telomerase homolog TP1Telomerase protein 1 TROVE domain family, member 1 TROVE1