TCF7L2 Products

Description

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both 946;-cell survival and function (4). Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression (3), and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine (1, 2).

Bioinformatics

Entrez	21416 Mouse 6934 Human
Uniprot	AAH32656 Human AAH32656.1 Human NP_001139746 Human NP_001139758 Human NP_110383 Human Q6FHW4 Human Q9NQB0 Human
Product By Gene ID	6934
Alternate Names	HMG box transcription factor 4 hTCF-4 T-cell factor 4 T-cell factor-4 variant A T-cell factor-4 variant B T-cell factor-4 variant C T-cell factor-4 variant D T-cell factor-4 variant E T-cell factor-4 variant H T-cell factor-4 variant I T-cell factor-4 variant J T-cell factor-4 variant K T-cell factor-4 variant L T-cell factor-4 variant M T-cell factor-4 variant X2 T-cell-specific transcription factor 4 TCF-4T-cell factor-4 variant F TCF4T-cell factor-4 variant G transcription factor 7-like 2 (T-cell specific, HMG-box) transcription factor 7-like 2

Research Areas for TCF7L2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction
Wnt Signaling Pathway