RAP80 Products

Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. TRAP80 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. TRAP80 is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This antibody was raised by a genetic immunization technique. Genetic immunization can be used to generate antibodies by directly delivering antigen-coding DNA into the animal, rather than injecting a protein or peptide (Tang et al. PubMed: 1545867; Chambers and Johnston PubMed 12910245; Barry and Johnston PubMed: 9234514). The animals cells produce the protein, which stimulates the animals immune system to produce antibodies against that particular protein. A vector coding for a partial fusion protein was used for genetic immunisation of a mouse and the resulting serum was tested in Western blot against an E.coli lysate containing that partial fusion protein. Genetic immunization offers enormous advantages over the traditional protein-based immunization method. DNA is faster, cheaper and easier to produce and can be produced by standard techniques readily amenable to automation. Furthermore, the antibodies generated by genetic immunization are usually of superior quality with regard to specificity, affinity and recognizing the native protein.

Bioinformatics

Entrez	51720 Human
Uniprot	AAH06078.1 Human EAW85043 Human NP_057374 Human NP_057374.3 Human Q96RL1 Human
Product By Gene ID	51720
Alternate Names	BRCA1-A complex subunit RAP80 RAP80X2HRIP110 receptor associated protein 80 Receptor-associated protein 80 retinoid x receptor interacting protein Retinoid X receptor-interacting protein 110 RXRIP110 ubiquitin interaction motif containing 1 Ubiquitin interaction motif-containing protein 1

Research Areas for RAP80

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer