PDZK1 Products

Description

PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, PDZK1 may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport, therefore playing an important role in tubule function .

Bioinformatics

Uniprot	AAH06496 Human NP_002605 Human Q13113 Human Q5T2W1 Human
Product By Gene ID	5174
Alternate Names	CAP70 CFTR-associated protein of 70 kDa CLAMP Na(+)/H(+) exchanger regulatory factor 3 Na/Pi cotransporter C-terminal-associated protein 1 NaPi-Cap1 naPi-Cap1 NHERF-3 NHERF3PDZD1Na(+)/H(+) exchange regulatory cofactor NHE-RF3 PDZ domain containing 1 PDZ domain-containing protein 1 PDZ-containing kidney protein 1 Sodium-hydrogen exchanger regulatory factor 3

Research Areas for PDZK1

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Diabetes Research
Endothelial Cell Markers
Growth and Development
Lipid and Metabolism
Neuronal Cell Markers
Plasma Membrane Markers
Signal Transduction