LYK5 Products

Description

The protein encoded by the LYK5 gene contains a STE20-like kinase domain, but lacks several residues that are critical forcatalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex withserine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39,also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has beenshown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcriptvariants encoding different isoforms have been found for this gene. Additional transcript variants have been describedbut their full-length nature is not known. (provided by RefSeq)

Bioinformatics

Entrez	72149 Mouse 92335 Human
Uniprot	NP_001003787 Human NP_699166 Human NP_699166.2 Human Q7RTN6 Human Q7RTN6-3 Human
Product By Gene ID	92335
Alternate Names	LYK5FLJ90524 NY-BR-96 protein kinase LYK5 Serologically defined breast cancer antigen NY-BR-96 STE20-like pseudokinase STE20-related adapter protein STE20-related adaptor protein STE20-related kinase adapter protein alpha STE20-related kinase adaptor alpha Stlk STRAD alpha STRADPMSE

Research Areas for LYK5

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Signal Transduction