Species: Hu, Mu, Rt, Dr
Applications: WB, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, ChIP
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The protein encoded by the JAB1 gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. (provided by RefSeq)
Bioinformatics
| Entrez |
Human
Rat
Mouse
Rat
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
10987 |
| Alternate Names |
- COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
- COP9 signalosome complex subunit 5
- CSN5COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5
- EC 3.4
- JAB138 kDa Mov34 homolog
- Jun activation domain-binding protein 1
- MOV-34
- SGN5MGC3149
- Signalosome subunit 5
|
Research Areas for JAB1
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction
