hnRNP M1-M4 Products

Description

Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.

Bioinformatics

Entrez	116655 Rat 4670 Human 76936 Mouse
Uniprot	P52272 Human
Product By Gene ID	4670
Alternate Names	DKFZp547H118 heterogeneous nuclear ribonucleoprotein M hnRNP M HNRNPM4 HNRPM4heterogenous nuclear ribonucleoprotein M HNRPMheterogenous nuclear ribonucleoprotein M4 HTGR1 M4 protein N-acetylglucosamine receptor 1 NAGR1hnRNA-binding protein M4

Research Areas for hnRNP M1-M4

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