GFM1 Products

Description

The GFM1 gene codes for a mitochondrial translation elongation factor G where one isoform is 751 amino acids long at around 83 kDA and another isoform is 770 amino acids in length at around 86 kDA. Mitochondrial translation is critical for maintaining mitochondrial function. Mutations may lead to a failure of the respiratory chain-oxidative phosphorylation system and maintenance of mitochondrial DNA will not be successful. GFM1 has been studied in relation to candidiasis, malaria, mycobacterium tuberculosis, hemophilia B, pneumonia, and combined oxidative phosphorylation deficiency. It interacts with TRIM63, SLX4, PRPF4, TRIM55, and SMURF2 to participate in protein biosynthesis and polypeptide chain elongation.

Bioinformatics

Entrez	85476 Human
Uniprot	NM_024996 Human NP_079272 Human NP_079272.4 Human Q96RP9 Human
Product By Gene ID	85476
Alternate Names	EFG EFG1FLJ12662 EFGM EF-Gmt EGF1 FLJ13632 FLJ20773 G elongation factor, mitochondrial 1 G translation elongation factor, mitochondrial GFMCOXPD1 hEFG1 mEF-G 1 mitochondrial elongation factor G mitochondrial elongation factor G1 mitochondrial mitochondrial