ECSIT Products

Description

Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

Bioinformatics

Entrez	26940 Mouse 51295 Human
Uniprot	AAH00193 Human NP_057665 Human Q9BQ95 Human
Product By Gene ID	51295
Alternate Names	ECSIT homolog (Drosophila) evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial likely ortholog of mouse signaling intermediate in Toll pathway evolutionarilyconserved Protein SITPEC signaling intermediate in Toll pathway evolutionarily conserved ortholog SITPECsignaling intermediate in Toll pathway, evolutionarily conserved

Research Areas for ECSIT

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Signal Transduction
Wnt Signaling Pathway