DDR2 Products

Description

DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Bioinformatics

Entrez	4921 Human
Uniprot	AAH52998 Human NM_006182 Human NM_006182. Human NM_006182.2 Human NP_001014796 Human NP_001014796.1 Human Q16832 Human
Product By Gene ID	4921
Alternate Names	CD167 antigen-like family member B CD167b antigen Discoidin domain receptor 2 discoidin domain receptor family, member 2 discoidin domain receptor tyrosine kinase 2 discoidin domain-containing receptor 2 EC 2.7.10 EC 2.7.10.1 hydroxyaryl-protein kinase migration-inducing gene 16 protein neurotrophic tyrosine kinase receptor related 3 Neurotrophic tyrosine kinase, receptor-related 3 NTRKR3cell migration-inducing protein 20 Receptor protein-tyrosine kinase TKT TKTMIG20a TYRO10 Tyrosine-protein kinase TYRO10 tyrosylprotein kinase