CD3 epsilon Products

Description

CD3 epsilon is a subunit of CD3. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

Bioinformatics

Entrez	12500 Mouse 12501 Mouse 315609 Rat 916 Human
Uniprot	AAH49847 Human AAH49847.1 Human NM_000733 Human NP_000724.1 Human P07766 Human P22646 Mouse
Product By Gene ID	916
Alternate Names	CD3e antigen CD3e antigen, epsilon polypeptide (TiT3 complex) CD3e molecule, epsilon (CD3-TCR complex) CD3e molecule, epsilon (CD3-TCR complex) CD3-epsilon FLJ18683 T3E T-cell antigen receptor complex, epsilon subunit of T3 T-cell surface antigen T3/Leu-4 epsilon chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 epsilon chain TCRE

Research Areas for CD3 epsilon

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
CD Markers
Cytokine Research
Diabetes Research
Immunology
Mesenchymal Stem Cell Markers
Signal Transduction
Stem Cell Lines
Stem Cell Markers