ATF2 Products

Description

ATF-2 (activating transcription factor-2, CRE-BP1) is a transcription factor that binds the cAMP response element (CRE) and AP-1 response element and is abundantly expressed in the brain. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2 (2). SAPK and p38 MAPK can activate, in response to cellular stress, ATF-2 by phosphorylating this protein at Thr69 and Thr71. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 (2-4).

Bioinformatics

Entrez	11909 Mouse 1386 Human 81647 Rat
Uniprot	AAH26175 Human AAH26175.1 Human AAY17203.1 Human NP_001871 Human NP_001871. Human NP_001871.2 Human P15336 Human
Product By Gene ID	1386
Alternate Names	activating transcription factor 2formerly cAMP responsive element binding protein 2 cAMP-responsive element-binding protein 2 CREBP1 cyclic AMP-dependent transcription factor ATF-2 MGC111558

Research Areas for ATF2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Immunology
Innate Immunity
Phospho-Specific
Transcription Factors and Regulators